G7JVE7 · G7JVE7_MEDTR

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site100-105FMN (UniProtKB | ChEBI)
Binding site155-158FMN (UniProtKB | ChEBI)
Binding site193-202FMN (UniProtKB | ChEBI)
Binding site228FMN (UniProtKB | ChEBI)
Binding site319NADP+ (UniProtKB | ChEBI)
Binding site479-482FAD (UniProtKB | ChEBI)
Binding site497-499FAD (UniProtKB | ChEBI)
Binding site513-516FAD (UniProtKB | ChEBI)
Binding site560NADP+ (UniProtKB | ChEBI)
Binding site621-622NADP+ (UniProtKB | ChEBI)
Binding site627-631NADP+ (UniProtKB | ChEBI)
Binding site663NADP+ (UniProtKB | ChEBI)
Binding site701FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      11424724
    • Synonyms
      CPR2
    • ORF names
      MtrunA17_Chr4g0072351
    • Ordered locus names
      MTR_4g128020

Organism names

  • Taxonomic identifier
  • Strains
    • A17
    • cv. Jemalong A17
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Trifolieae > Medicago

Accessions

  • Primary accession
    G7JVE7

Proteomes

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane41-61Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain94-244Flavodoxin-like
Domain299-546FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    701
  • Mass (Da)
    77,974
  • Last updated
    2012-01-25 v1
  • Checksum
    9C42A03CDE7A1E4E
MQDSSSMKFSPLDLMSALIKGKIDPSNGTVPASLILENREFVMILTTSIAVLIGCVVVLIWRRSNSQKPKPIEVPKRVIEKLPELEIDDGTKKVTVFFGTQTGTAEGFAKAIAEEAKARYEKAKFKVVDMDDYAADDDEYEEKLKKETMALFFLATYGDGEPTDNAARFYKWFEEFEGEEDSFKNLQYGVFGLGNRQYEHFNKVAKIVDDKLLEKGGNRLVPVGLGDDDQCIEDDFTAWKEELWPALDQLLRDEDDATVATPYTASVLEYRVVIRDQLDATVDEKKQLNGNGHAVVDAHHPVRANVAVRKELHTPASDRSCTHLEFDISGTGVVYETGDHVGVYCENLSDTVEEAERILGLSPDTYFSVHTDDEDGKPLGGSSLPPPFPPCTLRTALAKYADVLSSPKKSALLALAAHASDPSEADRLRHLASPAGKDEYAEWVIASQRSLLEVMAEFSSAKPPIGVFFASVAPRLQPRYYSISSSPRVAPSRIHVTCALVHDKMPTGRIHQGVCSTWMKNSAPLEKSQDCSWAPIFVRQSNFRLPADNKVPIIMIGPGTGLAPFRGFLQERLALKEEGAELGPSVLFFGCRNRQVDYIYEDELNHFVHGGALSELIVAFSREGPTKEYVQHKMIEKASDIWNMISQGAYIYVCGDAKGMAKDVHRTLHTILQEQGSLDNSKTESMVKNLQMTGRYLRDVW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001220
EMBL· GenBank· DDBJ
AES92306.1
EMBL· GenBank· DDBJ
Genomic DNA
KY798118
EMBL· GenBank· DDBJ
AUG98242.1
EMBL· GenBank· DDBJ
mRNA
PSQE01000004
EMBL· GenBank· DDBJ
RHN64738.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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