G7IKX3 · G7IKX3_MEDTR

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site96NAD+ (UniProtKB | ChEBI)
Binding site97NAD+ (UniProtKB | ChEBI)
Binding site166NAD+ (UniProtKB | ChEBI)
Binding site169NAD+ (UniProtKB | ChEBI)
Binding site170NAD+ (UniProtKB | ChEBI)
Binding site171NAD+ (UniProtKB | ChEBI)
Binding site228NAD+ (UniProtKB | ChEBI)
Binding site251NAD+ (UniProtKB | ChEBI)
Binding site275NAD+ (UniProtKB | ChEBI)
Binding site277NAD+ (UniProtKB | ChEBI)
Binding site277substrate
Binding site299Zn2+ (UniProtKB | ChEBI)
Binding site299substrate
Binding site302Zn2+ (UniProtKB | ChEBI)
Binding site302substrate
Active site367Proton acceptor
Active site368Proton acceptor
Binding site368substrate
Binding site401Zn2+ (UniProtKB | ChEBI)
Binding site401substrate
Binding site410NAD+ (UniProtKB | ChEBI)
Binding site455substrate
Binding site460Zn2+ (UniProtKB | ChEBI)
Binding site460substrate

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentcytoplasm
Molecular Functionhistidinol dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase, chloroplastic
  • Short names
    HDH

Gene names

    • Name
      11412251
    • ORF names
      MtrunA17_Chr2g0292691
    • Ordered locus names
      MTR_2g030520

Organism names

  • Taxonomic identifier
  • Strains
    • A17
    • cv. Jemalong A17
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Trifolieae > Medicago

Accessions

  • Primary accession
    G7IKX3

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    52,045
  • Last updated
    2012-01-25 v1
  • Checksum
    FC10BF07FB86D8FE
MKSALTTCNINWKCYQNHHRTSFSVTNTINYRTRCSISMANPIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQVSR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001218
EMBL· GenBank· DDBJ
AES64804.1
EMBL· GenBank· DDBJ
Genomic DNA
PSQE01000002
EMBL· GenBank· DDBJ
RHN72894.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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