G6Y6U9 · G6Y6U9_9HYPH

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site18-23NAD+ (UniProtKB | ChEBI)
Binding site22NADPH (UniProtKB | ChEBI)
Binding site42NADPH (UniProtKB | ChEBI)
Binding site58NADPH (UniProtKB | ChEBI)
Binding site115NADPH (UniProtKB | ChEBI)
Binding site115sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site115substrate
Binding site143sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site145sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site147NAD+ (UniProtKB | ChEBI)
Binding site147NADPH (UniProtKB | ChEBI)
Active site198Proton acceptor
Binding site198sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site251sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site261sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site262NAD+ (UniProtKB | ChEBI)
Binding site262NADPH (UniProtKB | ChEBI)
Binding site262sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site262-263substrate
Binding site263sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site281NADPH (UniProtKB | ChEBI)
Binding site283NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      MEA186_08323

Organism names

  • Taxonomic identifier
  • Strain
    • CCNWGS0123
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Phyllobacteriaceae > Mesorhizobium

Accessions

  • Primary accession
    G6Y6U9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-167Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain187-322Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    34,213
  • Last updated
    2012-01-25 v1
  • Checksum
    689FF671B152142F
MTGGEDRAPSGWRVAVLGGGAWGTALALAMLRAGHFVRLYARDPETVAAIDHGENPRYLPGIAIEPGIVATSDIRAALDGADCVLAVAPAQALRSMLAAAKDHVPKSIPLVLCAKGIERDTGALLSTIVENILPENPVAALSGPSFATDVARGLPTAVVVAARDADLAADLAARFSAENLRCYSSDDLVGVEIGGALKNVFAIAAGAVTGAKLGASAQAAMVTRGFVELRRIGAAFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLALGQGKPLAGLPLAEGVPTAAIAARIAIERQIDAPIITAIAAILEGTVTVRQAVSALMTRPLKTETDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGSN01000078
EMBL· GenBank· DDBJ
EHH12509.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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