G6XF57 · G6XF57_9PROT

Function

function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentDNA polymerase III complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA-templated DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase III subunit gamma/tau
  • EC number

Gene names

    • Name
      dnaX
    • ORF names
      GMO_01220

Organism names

  • Taxonomic identifier
  • Strain
    • G707
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Gluconobacter

Accessions

  • Primary accession
    G6XF57

Proteomes

Subcellular Location

Interaction

Subunit

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain74-221AAA+ ATPase
Region422-459Disordered
Compositional bias426-455Polar residues

Sequence similarities

Belongs to the DnaX/STICHEL family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    647
  • Mass (Da)
    70,028
  • Last updated
    2012-01-25 v1
  • Checksum
    FC749D7DD3C6D351
MTDENDALPLPPENGGGFFGNVPASAPVEAHPEPAEAAPYRVLARKYRPQTFDNLIGQDSLVRILRRAFELNRVAHAFMLTGVRGVGKTTTARIIARALNCIGPDGKGGPTADPCGVCVNCKAILADRHPDVLEMDAASRTGVDDVREIIEATRFRPMQARMKVFIIDEVHMLSRNAFNALLKTLEEPPPQVTFIFATTELRKVPVTVLSRCQRFDLRRVPQSLLAGHFRTIAQQEGATLSDDAFSLIARAADGSVRDGLSLLDQAIAQGASDAAAVSDMLGLADRGLVFDLLEALMAGRIAEALEISDQAYAHGADLGVLLTDLLDLLHLVSRLKAVPTLRDGRDLPEAERLRGGALADRLSNTALGRAWQILLKGVQEVESAPDRRQAAEMVLIRLCHASQLPTPDRLIRQLTEGGADLTLPVSAGSSGPSTSQASSLSASSRRMTETSGNHGPQARVRLVANGGRIIVHDASPAQPDLPPEPELPPAPRTWREMVALTREKQPLLHGTLRNAVHLVRFSPPDVQIRLEDSQTKADRRLQAFLDELFPGVWRISLSTAEGEPTLDEQGAEVVALNRASVEAHPLVQAILEAFPGARIGEVQDHSLDEYGLPPEITTPLVENAPPDLEFAPLDADFPDEDDHYLNG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias426-455Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGQV01000001
EMBL· GenBank· DDBJ
EHH68815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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