G5EFX6 · SLIT1_CAEEL

  • Protein
    Slit homolog 1 protein
  • Gene
    slt-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functionheparin binding
Molecular FunctionRoundabout binding
Molecular Functionsignaling receptor binding
Biological Processaxon guidance
Biological Processaxon midline choice point recognition
Biological Processdorsal/ventral axon guidance
Biological Processnegative regulation of axon extension involved in axon guidance
Biological Processneuron migration
Biological Processregulation of sensory neuron axon guidance
Biological Processsensory neuron axon guidance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Slit homolog 1 protein
  • Short names
    Slt-1

Gene names

    • Name
      slt-1
    • ORF names
      F40E10.4

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    G5EFX6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000042095817-1410Slit homolog 1 protein
Disulfide bond873↔884
Disulfide bond878↔894
Disulfide bond896↔905
Disulfide bond912↔923
Disulfide bond917↔933
Disulfide bond935↔944
Disulfide bond951↔962
Disulfide bond956↔971
Disulfide bond973↔982
Disulfide bond989↔1002
Disulfide bond996↔1011
Disulfide bond1013↔1022
Disulfide bond1029↔1040
Disulfide bond1034↔1049
Disulfide bond1051↔1060
Disulfide bond1076↔1086
Disulfide bond1081↔1097
Disulfide bond1099↔1108
Disulfide bond1259↔1285
Disulfide bond1292↔1302
Disulfide bond1297↔1314
Disulfide bond1316↔1325
Disulfide bond1332↔1368
Disulfide bond1346↔1382
Disulfide bond1357↔1398
Disulfide bond1361↔1400

Keywords

Proteomic databases

Expression

Gene expression databases

    • WBGene00004854Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Interacts with eva-1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain17-43LRRNT 1
Repeat22-42LRR 1
Repeat43-66LRR 2
Repeat67-90LRR 3
Repeat91-114LRR 4
Repeat116-138LRR 5
Repeat140-162LRR 6
Repeat163-186LRR 7
Domain195-243LRRCT 1
Repeat219-242LRR 8
Domain259-286LRRNT 2
Repeat286-309LRR 9
Repeat310-333LRR 10
Repeat335-357LRR 11
Repeat358-381LRR 12
Repeat383-405LRR 13
Repeat407-430LRR 14
Domain417-466LRRCT 2
Repeat442-465LRR 15
Domain484-511LRRNT 3
Repeat489-510LRR 16
Repeat511-535LRR 17
Repeat536-559LRR 18
Repeat561-583LRR 19
Repeat585-607LRR 20
Domain619-671LRRCT 3
Domain677-703LRRNT 4
Repeat681-703LRR 21
Repeat704-726LRR 22
Repeat727-750LRR 23
Repeat752-774LRR 24
Repeat775-798LRR 25
Repeat800-823LRR 26
Domain810-859LRRCT 4
Domain871-906EGF-like 1
Domain908-945EGF-like 2
Domain947-983EGF-like 1; calcium-binding
Domain985-1023EGF-like 3
Domain1025-1061EGF-like 2; calcium-binding
Domain1072-1109EGF-like 4
Domain1112-1285Laminin G-like
Repeat1197-1221LRR 27
Domain1288-1326EGF-like 5
Domain1332-1406CTCK

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,410
  • Mass (Da)
    158,223
  • Last updated
    2011-12-14 v1
  • Checksum
    D33716A9C98EBA9D
MLICFIFILLIPESATCPAECVCVDRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDFSSLMNLKALQLMDNQIVTIHNQSFSSLVFLQKLRLSRNRIRHLPDNVFQNNLKLTHLDLSENDITVVSDAQLQGPEFLEVLNLDKNHIFCLENNVISSWVSLEVLTLNGNRLTTFEEPSNARFRQLDLFNNPWNCDCRLRWMRKWLEKAEGQNKTVCATPLNLQGSSIEILQDKFMTCSGNRKRRYKKTCETAEICPLPCTCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQISSIPSHSFKNLKNLTRLDLSKNIITEIQPKAFLGLHNLHTLVLYGNNITDLKSDTFEGLGSLQLLLLNANQLTCIRRGTFDHVPKLSMLSLYDNDIKSISEVTFQNLTSLSTLHLAKNPLICDCNLQWLAQINLQKNIETSGARCEQPKRLRKKKFATLPPNKFKCKGSESFVSMYADSCFIDSICPTQCDCYGTTVDCNKRGLNTIPTSIPRFATQLLLSGNNISTVDLNSNIHVLENLEVLDLSNNHITFINDKSFEKLSKLRELRLNDNKLHHFSSMVLDEQSNLEILDLSGNNIQCFSSIFFNKATRIREIKVIGNDLLCDCRILPLMSWLRSNSSHSIDIPPCQQFQYSDNESDKQRCAAFPEETCSDDSNLCPPKCSCLDRVVRCSNKNLTSFPSRIPFDTTELYLDANYINEIPAHDLNRLYSLTKLDLSHNRLISLENNTFSNLTRLSTLIISYNKLRCLQPLAFNGLNALRILSLHGNDISFLPQSAFSNLTSITHIAVGSNSLYCDCNMAWFSKWIKSKFIEAGIARCEYPNTVSNQLLLTAQPYQFTCDSKVPTKLATKCDLCLNSPCKNNAICETTSSRKYTCNCTPGFYGVHCENQIDACYGSPCLNNATCKVAQAGRFNCYCNKGFEGDYCEKNIDDCVNSKCENGGKCVDLINSYRCDCPMEYEGKHCEDKLEYCTKKLNPCENNGKCIPINGSYSCMCSPGFTGNNCETNIDDCKNVECQNGGSCVDGILSYDCLCRPGYAGQYCEIPPMMDMEYQKTDACQQSACGQGECVASQNSSDFTCKCHEGFSGPSCDRQMSVGFKNPGAYLALDPLASDGTITMTLRTTSKIGILLYYGDDHFVSAELYDGRVKLVYYIGNFPASHMYSSVKVNDGLPHRISIRTSERKCFLQIDKNPVQIVENSGKSDQLITKGKEMLYIGGLPIEKSQDAKRRFHVKNSESLKGCISSITINEVPINLQQALENVNTEQSCSATVNFCAGIDCGNGKCTNNALSPKGYMCQCDSHFSGEHCDEKRIKCDKQKFRRHHIENECRSVDRIKIAECNGYCGGEQNCCTAVKKKQRKVKMICKNGTTKISTVHIIRQCQCEPTKSVLSEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z69792
EMBL· GenBank· DDBJ
CAA93668.3
EMBL· GenBank· DDBJ
Genomic DNA
AL022270
EMBL· GenBank· DDBJ
CAA93668.3
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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