G5EFX6 · SLIT1_CAEEL
- ProteinSlit homolog 1 protein
- Geneslt-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1410 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Molecular Function | heparin binding | |
Molecular Function | Roundabout binding | |
Molecular Function | signaling receptor binding | |
Biological Process | axon guidance | |
Biological Process | axon midline choice point recognition | |
Biological Process | dorsal/ventral axon guidance | |
Biological Process | negative regulation of axon extension involved in axon guidance | |
Biological Process | neuron migration | |
Biological Process | regulation of sensory neuron axon guidance | |
Biological Process | sensory neuron axon guidance |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSlit homolog 1 protein
- Short namesSlt-1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionG5EFX6
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MLICFIFILLIPESAT | ||||||
Chain | PRO_0000420958 | 17-1410 | Slit homolog 1 protein | |||
Sequence: CPAECVCVDRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDFSSLMNLKALQLMDNQIVTIHNQSFSSLVFLQKLRLSRNRIRHLPDNVFQNNLKLTHLDLSENDITVVSDAQLQGPEFLEVLNLDKNHIFCLENNVISSWVSLEVLTLNGNRLTTFEEPSNARFRQLDLFNNPWNCDCRLRWMRKWLEKAEGQNKTVCATPLNLQGSSIEILQDKFMTCSGNRKRRYKKTCETAEICPLPCTCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQISSIPSHSFKNLKNLTRLDLSKNIITEIQPKAFLGLHNLHTLVLYGNNITDLKSDTFEGLGSLQLLLLNANQLTCIRRGTFDHVPKLSMLSLYDNDIKSISEVTFQNLTSLSTLHLAKNPLICDCNLQWLAQINLQKNIETSGARCEQPKRLRKKKFATLPPNKFKCKGSESFVSMYADSCFIDSICPTQCDCYGTTVDCNKRGLNTIPTSIPRFATQLLLSGNNISTVDLNSNIHVLENLEVLDLSNNHITFINDKSFEKLSKLRELRLNDNKLHHFSSMVLDEQSNLEILDLSGNNIQCFSSIFFNKATRIREIKVIGNDLLCDCRILPLMSWLRSNSSHSIDIPPCQQFQYSDNESDKQRCAAFPEETCSDDSNLCPPKCSCLDRVVRCSNKNLTSFPSRIPFDTTELYLDANYINEIPAHDLNRLYSLTKLDLSHNRLISLENNTFSNLTRLSTLIISYNKLRCLQPLAFNGLNALRILSLHGNDISFLPQSAFSNLTSITHIAVGSNSLYCDCNMAWFSKWIKSKFIEAGIARCEYPNTVSNQLLLTAQPYQFTCDSKVPTKLATKCDLCLNSPCKNNAICETTSSRKYTCNCTPGFYGVHCENQIDACYGSPCLNNATCKVAQAGRFNCYCNKGFEGDYCEKNIDDCVNSKCENGGKCVDLINSYRCDCPMEYEGKHCEDKLEYCTKKLNPCENNGKCIPINGSYSCMCSPGFTGNNCETNIDDCKNVECQNGGSCVDGILSYDCLCRPGYAGQYCEIPPMMDMEYQKTDACQQSACGQGECVASQNSSDFTCKCHEGFSGPSCDRQMSVGFKNPGAYLALDPLASDGTITMTLRTTSKIGILLYYGDDHFVSAELYDGRVKLVYYIGNFPASHMYSSVKVNDGLPHRISIRTSERKCFLQIDKNPVQIVENSGKSDQLITKGKEMLYIGGLPIEKSQDAKRRFHVKNSESLKGCISSITINEVPINLQQALENVNTEQSCSATVNFCAGIDCGNGKCTNNALSPKGYMCQCDSHFSGEHCDEKRIKCDKQKFRRHHIENECRSVDRIKIAECNGYCGGEQNCCTAVKKKQRKVKMICKNGTTKISTVHIIRQCQCEPTKSVLSEK | ||||||
Disulfide bond | 873↔884 | |||||
Sequence: CLNSPCKNNAIC | ||||||
Disulfide bond | 878↔894 | |||||
Sequence: CKNNAICETTSSRKYTC | ||||||
Disulfide bond | 896↔905 | |||||
Sequence: CTPGFYGVHC | ||||||
Disulfide bond | 912↔923 | |||||
Sequence: CYGSPCLNNATC | ||||||
Disulfide bond | 917↔933 | |||||
Sequence: CLNNATCKVAQAGRFNC | ||||||
Disulfide bond | 935↔944 | |||||
Sequence: CNKGFEGDYC | ||||||
Disulfide bond | 951↔962 | |||||
Sequence: CVNSKCENGGKC | ||||||
Disulfide bond | 956↔971 | |||||
Sequence: CENGGKCVDLINSYRC | ||||||
Disulfide bond | 973↔982 | |||||
Sequence: CPMEYEGKHC | ||||||
Disulfide bond | 989↔1002 | |||||
Sequence: CTKKLNPCENNGKC | ||||||
Disulfide bond | 996↔1011 | |||||
Sequence: CENNGKCIPINGSYSC | ||||||
Disulfide bond | 1013↔1022 | |||||
Sequence: CSPGFTGNNC | ||||||
Disulfide bond | 1029↔1040 | |||||
Sequence: CKNVECQNGGSC | ||||||
Disulfide bond | 1034↔1049 | |||||
Sequence: CQNGGSCVDGILSYDC | ||||||
Disulfide bond | 1051↔1060 | |||||
Sequence: CRPGYAGQYC | ||||||
Disulfide bond | 1076↔1086 | |||||
Sequence: CQQSACGQGEC | ||||||
Disulfide bond | 1081↔1097 | |||||
Sequence: CGQGECVASQNSSDFTC | ||||||
Disulfide bond | 1099↔1108 | |||||
Sequence: CHEGFSGPSC | ||||||
Disulfide bond | 1259↔1285 | |||||
Sequence: CISSITINEVPINLQQALENVNTEQSC | ||||||
Disulfide bond | 1292↔1302 | |||||
Sequence: CAGIDCGNGKC | ||||||
Disulfide bond | 1297↔1314 | |||||
Sequence: CGNGKCTNNALSPKGYMC | ||||||
Disulfide bond | 1316↔1325 | |||||
Sequence: CDSHFSGEHC | ||||||
Disulfide bond | 1332↔1368 | |||||
Sequence: CDKQKFRRHHIENECRSVDRIKIAECNGYCGGEQNCC | ||||||
Disulfide bond | 1346↔1382 | |||||
Sequence: CRSVDRIKIAECNGYCGGEQNCCTAVKKKQRKVKMIC | ||||||
Disulfide bond | 1357↔1398 | |||||
Sequence: CNGYCGGEQNCCTAVKKKQRKVKMICKNGTTKISTVHIIRQC | ||||||
Disulfide bond | 1361↔1400 | |||||
Sequence: CGGEQNCCTAVKKKQRKVKMICKNGTTKISTVHIIRQCQC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-43 | LRRNT 1 | ||||
Sequence: CPAECVCVDRTVSCVGQQLTEVPQNIP | ||||||
Repeat | 22-42 | LRR 1 | ||||
Sequence: VCVDRTVSCVGQQLTEVPQNI | ||||||
Repeat | 43-66 | LRR 2 | ||||
Sequence: PNDTIRLDLQDNEITKIGPNDFSS | ||||||
Repeat | 67-90 | LRR 3 | ||||
Sequence: LMNLKALQLMDNQIVTIHNQSFSS | ||||||
Repeat | 91-114 | LRR 4 | ||||
Sequence: LVFLQKLRLSRNRIRHLPDNVFQN | ||||||
Repeat | 116-138 | LRR 5 | ||||
Sequence: LKLTHLDLSENDITVVSDAQLQG | ||||||
Repeat | 140-162 | LRR 6 | ||||
Sequence: EFLEVLNLDKNHIFCLENNVISS | ||||||
Repeat | 163-186 | LRR 7 | ||||
Sequence: WVSLEVLTLNGNRLTTFEEPSNAR | ||||||
Domain | 195-243 | LRRCT 1 | ||||
Sequence: NPWNCDCRLRWMRKWLEKAEGQNKTVCATPLNLQGSSIEILQDKFMTCS | ||||||
Repeat | 219-242 | LRR 8 | ||||
Sequence: TVCATPLNLQGSSIEILQDKFMTC | ||||||
Domain | 259-286 | LRRNT 2 | ||||
Sequence: ICPLPCTCTGTTVDCRDSGLTYVPTNLP | ||||||
Repeat | 286-309 | LRR 9 | ||||
Sequence: PPSTTEIRLEQNQISSIPSHSFKN | ||||||
Repeat | 310-333 | LRR 10 | ||||
Sequence: LKNLTRLDLSKNIITEIQPKAFLG | ||||||
Repeat | 335-357 | LRR 11 | ||||
Sequence: HNLHTLVLYGNNITDLKSDTFEG | ||||||
Repeat | 358-381 | LRR 12 | ||||
Sequence: LGSLQLLLLNANQLTCIRRGTFDH | ||||||
Repeat | 383-405 | LRR 13 | ||||
Sequence: PKLSMLSLYDNDIKSISEVTFQN | ||||||
Repeat | 407-430 | LRR 14 | ||||
Sequence: TSLSTLHLAKNPLICDCNLQWLAQ | ||||||
Domain | 417-466 | LRRCT 2 | ||||
Sequence: NPLICDCNLQWLAQINLQKNIETSGARCEQPKRLRKKKFATLPPNKFKCK | ||||||
Repeat | 442-465 | LRR 15 | ||||
Sequence: ARCEQPKRLRKKKFATLPPNKFKC | ||||||
Domain | 484-511 | LRRNT 3 | ||||
Sequence: ICPTQCDCYGTTVDCNKRGLNTIPTSIP | ||||||
Repeat | 489-510 | LRR 16 | ||||
Sequence: CDCYGTTVDCNKRGLNTIPTSI | ||||||
Repeat | 511-535 | LRR 17 | ||||
Sequence: PRFATQLLLSGNNISTVDLNSNIHV | ||||||
Repeat | 536-559 | LRR 18 | ||||
Sequence: LENLEVLDLSNNHITFINDKSFEK | ||||||
Repeat | 561-583 | LRR 19 | ||||
Sequence: SKLRELRLNDNKLHHFSSMVLDE | ||||||
Repeat | 585-607 | LRR 20 | ||||
Sequence: SNLEILDLSGNNIQCFSSIFFNK | ||||||
Domain | 619-671 | LRRCT 3 | ||||
Sequence: NDLLCDCRILPLMSWLRSNSSHSIDIPPCQQFQYSDNESDKQRCAAFPEETCS | ||||||
Domain | 677-703 | LRRNT 4 | ||||
Sequence: CPPKCSCLDRVVRCSNKNLTSFPSRIP | ||||||
Repeat | 681-703 | LRR 21 | ||||
Sequence: CSCLDRVVRCSNKNLTSFPSRIP | ||||||
Repeat | 704-726 | LRR 22 | ||||
Sequence: FDTTELYLDANYINEIPAHDLNR | ||||||
Repeat | 727-750 | LRR 23 | ||||
Sequence: LYSLTKLDLSHNRLISLENNTFSN | ||||||
Repeat | 752-774 | LRR 24 | ||||
Sequence: TRLSTLIISYNKLRCLQPLAFNG | ||||||
Repeat | 775-798 | LRR 25 | ||||
Sequence: LNALRILSLHGNDISFLPQSAFSN | ||||||
Repeat | 800-823 | LRR 26 | ||||
Sequence: TSITHIAVGSNSLYCDCNMAWFSK | ||||||
Domain | 810-859 | LRRCT 4 | ||||
Sequence: NSLYCDCNMAWFSKWIKSKFIEAGIARCEYPNTVSNQLLLTAQPYQFTCD | ||||||
Domain | 871-906 | EGF-like 1 | ||||
Sequence: DLCLNSPCKNNAICETTSSRKYTCNCTPGFYGVHCE | ||||||
Domain | 908-945 | EGF-like 2 | ||||
Sequence: QIDACYGSPCLNNATCKVAQAGRFNCYCNKGFEGDYCE | ||||||
Domain | 947-983 | EGF-like 1; calcium-binding | ||||
Sequence: NIDDCVNSKCENGGKCVDLINSYRCDCPMEYEGKHCE | ||||||
Domain | 985-1023 | EGF-like 3 | ||||
Sequence: KLEYCTKKLNPCENNGKCIPINGSYSCMCSPGFTGNNCE | ||||||
Domain | 1025-1061 | EGF-like 2; calcium-binding | ||||
Sequence: NIDDCKNVECQNGGSCVDGILSYDCLCRPGYAGQYCE | ||||||
Domain | 1072-1109 | EGF-like 4 | ||||
Sequence: KTDACQQSACGQGECVASQNSSDFTCKCHEGFSGPSCD | ||||||
Domain | 1112-1285 | Laminin G-like | ||||
Sequence: MSVGFKNPGAYLALDPLASDGTITMTLRTTSKIGILLYYGDDHFVSAELYDGRVKLVYYIGNFPASHMYSSVKVNDGLPHRISIRTSERKCFLQIDKNPVQIVENSGKSDQLITKGKEMLYIGGLPIEKSQDAKRRFHVKNSESLKGCISSITINEVPINLQQALENVNTEQSC | ||||||
Repeat | 1197-1221 | LRR 27 | ||||
Sequence: TSERKCFLQIDKNPVQIVENSGKSD | ||||||
Domain | 1288-1326 | EGF-like 5 | ||||
Sequence: TVNFCAGIDCGNGKCTNNALSPKGYMCQCDSHFSGEHCD | ||||||
Domain | 1332-1406 | CTCK | ||||
Sequence: CDKQKFRRHHIENECRSVDRIKIAECNGYCGGEQNCCTAVKKKQRKVKMICKNGTTKISTVHIIRQCQCEPTKSV |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,410
- Mass (Da)158,223
- Last updated2011-12-14 v1
- ChecksumD33716A9C98EBA9D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z69792 EMBL· GenBank· DDBJ | CAA93668.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL022270 EMBL· GenBank· DDBJ | CAA93668.3 EMBL· GenBank· DDBJ | Genomic DNA |