spindle assembly checkpoint components MAD-1 MAD-2 and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response.
Data show that doubling the CYB-3 (Cyclin B3) dosage suppresses sterility in the absence of the essential spindle assembly checkpoint component MDF-1 without causing a delay in the onset of anaphase.
MDF-1 causes the primordial germ cells arrest by two mechanisms one involving MDF-2 and another that is independent of other spindle assembly checkpoint components.
Deletion of the spindle checkpoint gene mdf-1 blocks lissencephaly disease gene lis-1-induced cell cycle arrest and germline apoptosis placing the spindle checkpoint pathway upstream of the programmed cell death pathway.
describe 11 suppressors of the mdf-1(gk2) lethality 10 identified in an ethyl methanesulfonate (EMS) mutagenesis screen and 1 isolated using the dog-1(gk10) (deletions of guanine-rich DNA) mutator strain
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