G5EEM6 · TAB1_CAEEL

  • Protein
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • Gene
    tap-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the Wnt signaling pathway by regulating mom-4 kinase activity.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.

Features

Showing features for site.

138650100150200250300350
TypeIDPosition(s)Description
Site364Required for interaction with mom-4

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionmitogen-activated protein kinase binding
Molecular Functionmitogen-activated protein kinase kinase kinase binding
Molecular Functionprotein kinase activator activity
Molecular Functionprotein serine/threonine phosphatase activity
Biological Processendodermal cell fate specification
Biological Processnegative regulation of gene expression, epigenetic
Biological Processnegative regulation of Ras protein signal transduction

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • Alternative names
    • TAB1-like protein 1
    • TAK1 kinase/MOM-4 binding Protein

Gene names

    • Name
      tap-1
    • ORF names
      C44H4.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    G5EEM6

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown causes no obvious phenotype. Results in a 3-fold increase in the number of animals lacking a gut in a mom-4 (or11) mutant background.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis364Abolishes interaction with mom-4.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004369061-386TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Proteomic databases

Expression

Gene expression databases

    • WBGene00006524Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Interacts with mom-4; the interaction enhances mom-4 kinase activity.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-327PPM-type phosphatase

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    43,469
  • Last updated
    2011-12-14 v1
  • Checksum
    957D1DC9F2914554
MGDDGFLDQYPANTDAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFENVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFARKHRDAYTMSDDKNFCISNHREEMTVIYVKLEEDYQAALYEQFDSAISTMESTNATLYEPCSTPYVDATNFNSGKNYEKMKKLLLTRPSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF145375
EMBL· GenBank· DDBJ
AAD39814.1
EMBL· GenBank· DDBJ
mRNA
BX284606
EMBL· GenBank· DDBJ
CAB01866.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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