G5EEI8 · CHRD1_CAEEL

  • Protein
    Cysteine and histidine-rich domain-containing protein 1
  • Gene
    chp-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Regulates centrosome duplication (By similarity).
Controls the secretion of the tyrosine kinase receptor let-23/EGFR from the endoplasmic reticulum and is required for the localization of let-23/EGFR to the plasma membrane of vulval precursor cells (PubMed:32053105).
It thus plays a role in positively regulating let/EGFR signaling, and anchor cell and vulval precursor cell alignment (PubMed:32053105).
Plays a role in vulval development and morphogenesis (PubMed:10571178, PubMed:32053105).

Features

Showing features for binding site.

132150100150200250300
TypeIDPosition(s)Description
Binding site9Zn2+ 1 (UniProtKB | ChEBI)
Binding site14Zn2+ 1 (UniProtKB | ChEBI)
Binding site28Zn2+ 1 (UniProtKB | ChEBI)
Binding site31Zn2+ 2 (UniProtKB | ChEBI)
Binding site46Zn2+ 2 (UniProtKB | ChEBI)
Binding site47Zn2+ 2 (UniProtKB | ChEBI)
Binding site63Zn2+ 2 (UniProtKB | ChEBI)
Binding site68Zn2+ 1 (UniProtKB | ChEBI)
Binding site152Zn2+ 3 (UniProtKB | ChEBI)
Binding site157Zn2+ 3 (UniProtKB | ChEBI)
Binding site170Zn2+ 3 (UniProtKB | ChEBI)
Binding site173Zn2+ 4 (UniProtKB | ChEBI)
Binding site188Zn2+ 4 (UniProtKB | ChEBI)
Binding site189Zn2+ 4 (UniProtKB | ChEBI)
Binding site205Zn2+ 4 (UniProtKB | ChEBI)
Binding site210Zn2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionzinc ion binding
Biological Processcentrosome duplication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine and histidine-rich domain-containing protein 1
  • Alternative names
    • CHORD domain-containing protein 1
      (CHORD-containing protein 1
      )
    • Protein CHORD

Gene names

    • Name
      chp-1
    • Synonyms
      chp
    • ORF names
      Y110A7A.13

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    G5EEI8

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in reduced fertility and in high levels of embryonic lethality with none of the unhatched embryos reaching the comma stage of development (PubMed:10571178).
Among the 40% of embryos that hatch, 98% reach adulthood, but have a reduced brood size, and the remaining 2% do not survive beyond the L1 larval stage (PubMed:10571178).
Surviving adults have defects in vulval development, whereby 3-5% have a protruding vulva (Pvl) phenotype and 1% have a multivulva (Mvl) phenotype (PubMed:10571178).
Occasionally, some adults have one missing gonadal arm, but many adults have defects in the organization of the proximal arm of the gonad, which are filled with smaller cells instead of full sized oocytes (PubMed:10571178).
RNAi-mediated knockdown results in reduced plasma membrane localization and increased intracellular accumulation of let-23 in vulval precursor cells P6.p and their descendants (PubMed:32053105).
RNAi-mediated knockdown does not affect the membrane localization of lin-12, lin-18 or pat-3 (PubMed:32053105).
RNAi-mediated knockdown in vulval precursor cells results in the intracellular accumulation of let-23 in 31% of cases (PubMed:32053105).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004504411-321Cysteine and histidine-rich domain-containing protein 1

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-68CHORD 1
Domain152-210CHORD 2
Domain218-308CS

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    36,007
  • Last updated
    2011-12-14 v1
  • Checksum
    8FF2228055BE2FBE
MVDESKLQCYHKGCGLLFDPKENDNEACTYHPGGPYFHDAYKIWTCCDKKSTDFGTWMNYKGCTRGKHSNEKPVDIVKVAAVKEIRPEKEEDVIVWKGLNKSGKLDSKDATKRIEQNLNVEVTPGATAAIEKKLKEISEAAQSADIQIGAPCRNNGCSTEFDGSKNKENCQHHPGAAIFHEGMKYWSCCNKKTSNFGAFLEQVGCTSGEHKFRNNEIVSKFREDWFSSNGFVTINVYCRGALPETANIVSDGHTVRVSMKHGFGNASVDLDYDLWDEVIPEESRVVIGERKVEISLKQKHGTGWPRLKFDPELDAKNDEEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF192264
EMBL· GenBank· DDBJ
AAF18435.1
EMBL· GenBank· DDBJ
mRNA
BX284601
EMBL· GenBank· DDBJ
CCD66204.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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