G5EBD7 · 6PGDH_GLUOX

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NAD to NADH.

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.44 mM6-phosphogluconate
64 μMNAD+
440 μMNADP+
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
41.7 μmol/min/mg
kcat is 23 sec-1. Can use NAD or NADP, but has a clear preference for NAD in vivo.

Pathway

Carbohydrate degradation; pentose phosphate pathway.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site30-32NAD+ (UniProtKB | ChEBI)
Binding site101NAD+ (UniProtKB | ChEBI)
Binding site101substrate
Binding site127substrate
Binding site129substrate
Active site197Proton acceptor
Binding site200-201substrate
Active site204Proton donor
Binding site205substrate

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate metabolic process
Biological Processorganic acid catabolic process
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating
  • EC number
  • Short names
    6PGDH

Gene names

    • Ordered locus names
      GOX1705

Organism names

Accessions

  • Primary accession
    G5EBD7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004344361-3326-phosphogluconate dehydrogenase, NAD+-dependent, decarboxylating

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    35,876
  • Last updated
    2011-12-14 v1
  • Checksum
    2D7466AEF76E8B08
MRIGIIGLGRMGGNIAVRLTRHGHDVVVHDRTSEVTTSVVGRCEAGRATPADTLADMAKLLEGDEHRVVWVMLPAGAITEDCVQQLGGLLGRGDIIIDGGNTYYKDDVRRSAELAEKGISYVDVGTSGGVWGLERGYCMMFGGTKETAEYIDPILSALAPGIGDVPRTPGRDEAGHDPRAEQGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPILAEKDRFELNMGDIAEVWRRGSVVSSWLLDLTAEALTRSETLNEFSGEVADSGEGRWTIEAAIEEDVPAPVMTAALFTRFRSRSGNNFAEKILSAQRFGFGGHVEKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000009
EMBL· GenBank· DDBJ
AAW61445.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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