G5E948 · G5E948_HUMAN

  • Protein
    non-specific serine/threonine protein kinase
  • Gene
    MAP4K4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Features

Showing features for binding site.

113841002003004005006007008009001,0001,1001,2001,300
TypeIDPosition(s)Description
Binding site54ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functionprotein kinase activity
Biological Processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processnegative regulation of neuron projection regeneration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • Name
      MAP4K4

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    G5E948

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,161 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)5PRIDEPhosphoserine
Modified residue (large scale data)86PRIDEPhosphotyrosine
Modified residue (large scale data)175PRIDEPhosphoserine
Modified residue (large scale data)181PRIDEPhosphothreonine
Modified residue (large scale data)187PRIDEPhosphothreonine
Modified residue (large scale data)191PRIDEPhosphothreonine
Modified residue (large scale data)324PRIDEPhosphoserine
Modified residue (large scale data)326PRIDEPhosphoserine
Modified residue (large scale data)560PRIDEPhosphotyrosine
Modified residue (large scale data)579PRIDEPhosphoserine
Modified residue (large scale data)580PRIDEPhosphoserine
Modified residue (large scale data)602PRIDEPhosphoserine
Modified residue (large scale data)641PRIDEPhosphoserine
Modified residue (large scale data)643PRIDEPhosphoserine
Modified residue (large scale data)648PRIDEPhosphoserine
Modified residue (large scale data)704PRIDEPhosphothreonine
Modified residue (large scale data)705PRIDEPhosphothreonine
Modified residue (large scale data)706PRIDEPhosphoserine
Modified residue (large scale data)708PRIDEPhosphoserine
Modified residue (large scale data)716PRIDEPhosphoserine
Modified residue (large scale data)721PRIDEPhosphoserine
Modified residue (large scale data)726PRIDEPhosphoserine
Modified residue (large scale data)733PRIDEPhosphoserine
Modified residue (large scale data)734PRIDEPhosphothreonine
Modified residue (large scale data)735PRIDEPhosphoserine
Modified residue (large scale data)736PRIDEPhosphoserine
Modified residue (large scale data)755PRIDEPhosphoserine
Modified residue (large scale data)770PRIDEPhosphoserine
Modified residue (large scale data)774PRIDEPhosphoserine
Modified residue (large scale data)776PRIDEPhosphoserine
Modified residue (large scale data)778PRIDEPhosphoserine
Modified residue (large scale data)786PRIDEPhosphoserine
Modified residue (large scale data)787PRIDEPhosphoserine
Modified residue (large scale data)788PRIDEPhosphoserine
Modified residue (large scale data)790PRIDEPhosphoserine
Modified residue (large scale data)793PRIDEPhosphoserine
Modified residue (large scale data)795PRIDEPhosphoserine
Modified residue (large scale data)881PRIDEPhosphoserine
Modified residue (large scale data)882PRIDEPhosphoserine
Modified residue (large scale data)886PRIDEPhosphoserine
Modified residue (large scale data)890PRIDEPhosphothreonine
Modified residue (large scale data)892PRIDEPhosphoserine
Modified residue (large scale data)904PRIDEPhosphoserine
Modified residue (large scale data)909PRIDEPhosphothreonine
Modified residue (large scale data)911PRIDEPhosphoserine
Modified residue (large scale data)915PRIDEPhosphothreonine
Modified residue (large scale data)922PRIDEPhosphothreonine
Modified residue (large scale data)929PRIDEPhosphoserine
Modified residue (large scale data)970PRIDEPhosphothreonine
Modified residue (large scale data)985PRIDEPhosphothreonine
Modified residue (large scale data)987PRIDEPhosphoserine
Modified residue (large scale data)989PRIDEPhosphoserine
Modified residue (large scale data)990PRIDEPhosphoserine
Modified residue (large scale data)991PRIDEPhosphothreonine
Modified residue (large scale data)997PRIDEPhosphoserine
Modified residue (large scale data)998PRIDEPhosphoserine
Modified residue (large scale data)999PRIDEPhosphoserine
Modified residue (large scale data)1000PRIDEPhosphoserine
Modified residue (large scale data)1013PRIDEPhosphoserine
Modified residue (large scale data)1045PRIDEPhosphoserine
Modified residue (large scale data)1052PRIDEPhosphothreonine
Modified residue (large scale data)1058PRIDEPhosphoserine
Modified residue (large scale data)1060PRIDEPhosphothreonine
Modified residue (large scale data)1140PRIDEPhosphoserine
Modified residue (large scale data)1375PRIDEPhosphothreonine

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain25-289Protein kinase
Compositional bias306-320Basic and acidic residues
Region306-349Disordered
Compositional bias321-337Acidic residues
Region421-462Disordered
Region518-932Disordered
Compositional bias550-579Basic and acidic residues
Compositional bias598-612Polar residues
Compositional bias626-646Polar residues
Compositional bias647-661Basic and acidic residues
Compositional bias664-687Polar residues
Compositional bias705-739Polar residues
Compositional bias754-797Polar residues
Compositional bias800-816Basic and acidic residues
Compositional bias827-841Basic and acidic residues
Compositional bias851-870Acidic residues
Compositional bias874-893Polar residues
Region948-1000Disordered
Domain1071-1358CNH

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,384
  • Mass (Da)
    157,786
  • Last updated
    2022-05-25 v3
  • Checksum
    F9E94EEC11A0D836
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQQSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O95819M4K4_HUMANMAP4K41239
E7EX83E7EX83_HUMANMAP4K41038
E7ETN6E7ETN6_HUMANMAP4K4102
A0A0D9SEY1A0A0D9SEY1_HUMANMAP4K41320
H7C3Z6H7C3Z6_HUMANMAP4K4258
H7C360H7C360_HUMANMAP4K41170
H7C0P6H7C0P6_HUMANMAP4K41056
E7EN19E7EN19_HUMANMAP4K41235
E7ENQ1E7ENQ1_HUMANMAP4K41154

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias306-320Basic and acidic residues
Compositional bias321-337Acidic residues
Compositional bias550-579Basic and acidic residues
Compositional bias598-612Polar residues
Compositional bias626-646Polar residues
Compositional bias647-661Basic and acidic residues
Compositional bias664-687Polar residues
Compositional bias705-739Polar residues
Compositional bias754-797Polar residues
Compositional bias800-816Basic and acidic residues
Compositional bias827-841Basic and acidic residues
Compositional bias851-870Acidic residues
Compositional bias874-893Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005035
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC007005
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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