G5CVT8 · G5CVT8_TAPIN

Function

function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionalpha2-adrenergic receptor activity
Molecular Functionepinephrine binding
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processplatelet activation
Biological Processregulation of smooth muscle contraction
Biological Processregulation of vasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-2B adrenergic receptor
  • Alternative names
    • Alpha-2B adrenoreceptor

Gene names

    • Name
      adra2b

Organism names

Accessions

  • Primary accession
    G5CVT8

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-23Helical
Transmembrane30-48Helical
Transmembrane68-88Helical
Transmembrane109-130Helical
Transmembrane150-173Helical
Transmembrane355-375Helical

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain9-406G-protein coupled receptors family 1 profile
Region185-211Disordered
Region227-312Disordered
Compositional bias274-296Acidic residues

Sequence similarities

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    406
  • Mass (Da)
    44,450
  • Last updated
    2011-12-14 v1
  • Checksum
    E36E19A5594763F7
FLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSVGSFFAPCLIMILVYLRIYLIAKRSHLRGPRAKGGPGEGESKQPRPVPGGASASAKLPTLASHLAAAGEANGHSVPTGEKEEGETPEDSGTPALPPSWPALPNSGQAQKEGICGASPEEEGEEEEEEGEEEEEEGEEACEPQALAASPASACSPPLQQPQVSRVLATLRGQVLLGRGVGTAGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSS

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias274-296Acidic residues
Non-terminal residue406

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN413892
EMBL· GenBank· DDBJ
AEP17928.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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