G4X0Q0 · G4X0Q0_PANTC

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Mawa
    • Okech
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    G4X0Q0

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-41Helical
Transmembrane61-81Helical
Transmembrane93-110Helical
Transmembrane116-136Helical
Transmembrane148-167Helical
Transmembrane196-216Helical
Transmembrane223-244Helical
Transmembrane256-277Helical
Transmembrane284-303Helical
Transmembrane309-330Helical
Transmembrane351-373Helical
Transmembrane393-411Helical

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-109NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain112-402NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    51,624
  • Last updated
    2011-12-14 v1
  • Checksum
    D85FE2194BCD20CA
MLKLIIPTIMLLPLTWFSKKRMIWINTTTHSLIISTIPLLLFNQINNNLFSCSLSFSSDPLTTPLLMLTAWLLPLTIMASQRHLSNEPLSRKKLYLSMLISLQISLIMTFSATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNTWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVTAILIQTPWSFTGAIILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTSFSWSNTTLLLTGFNMLITALYSLYMFTTTQWGSLTHHINSMKPSFTRENTLMFLHLSPILLLSLNPDIITGFTS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JF727182
EMBL· GenBank· DDBJ
AEQ35867.1
EMBL· GenBank· DDBJ
Genomic DNA
JF727199
EMBL· GenBank· DDBJ
AEQ64665.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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