G4N7X0 · MST11_PYRO7

Function

function

Mitogen-activated protein kinase kinase kinase; part of the MST11-MST7-PMK1 MAP kinase (MAPK) cascade that is essential for appressorium formation, penetration and invasive growth (PubMed:15749760, PubMed:23454094).
The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes (PubMed:21283781).
MST11 acts as the upstream MAPKKK that directly phosphorylates MAPKK MST7 (Probable). MST11 but not MST7 may also be involved in the OSM1 MAPK pathway in response to osmotic stresses (PubMed:15749760).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site647-655ATP (UniProtKB | ChEBI)
Binding site670ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionMAP kinase activity
Biological Processpositive regulation of developmental process
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinae kinase MST11
  • EC number
  • Short names
    MAPKKK MST11
  • Alternative names
    • MEKK MST11

Gene names

    • Name
      MST11
    • ORF names
      MGG_14847

Organism names

Accessions

  • Primary accession
    G4N7X0

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Produces much less aerial hyphae and conidia and shows weakened cell walls and higher sensitivity to cell wall-degrading enzymes (PubMed:15749760).
Impairs the formation of appressoria and the ability to infect rice plants (PubMed:15749760, PubMed:23454094).

Miscellaneous

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004530971-915Mitogen-activated protein kinase kinae kinase MST11

Interaction

Subunit

Interacts with the adapter protein MST50.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-65Disordered
Domain65-128SAM
Region134-171Disordered
Compositional bias147-171Polar residues
Region183-249Disordered
Compositional bias187-249Polar residues
Domain263-353Ras-associating
Domain641-911Protein kinase

Domain

The N-terminal sterile alpha motif (SAM) domain, but not the Ras-associating (RA) domain, is essential for the function.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    915
  • Mass (Da)
    101,021
  • Last updated
    2011-12-14 v1
  • Checksum
    D5D67F423E255DB2
MAMLASKSPFPAPLATSGSGMMAGTAQASYPPSRRAPAVPPASQSFSPTESEFSDSDDHDSPKHWDEDKVCEYLRSVRCGEYEKLFRKNHINGENLLEMDKDVLKEMGIEKVGDRVRLFLSIKKLRTKAIAGQKKRNRDSFAGHESMYTPVSESPSKPFHSSSRVMPNPSVNKRYSRQIDLSGMAYDPSRPTTSSRPTSPLPSADFRTARTRNPYVGQQPTPTGSLRGLGSPPDSQANSRPVLTHTRTDSGMDGSLMAALPQNQDVIRVISTGGVTKVVKIADCNTCEEVMRVTLRKFALREDHERNYCFWVLSGLDPDPKQCRRLGDTELWRVIKDQKRPERNRLILRRVPAGEPGQSELERAAAIAMEEAQQSHSRAMDNVGARSQIKVQKVLGENWDNLQPPLSPVLYQDRERNVYNAARDLERPEPLDSGRLQPRRKVLRSFGGLRPPSELIASDLTTYFPDHPREDIDRTARLSMRRSARLSKVNSRLSVASSFSMASSIQDAPPIPTIADSWLQSTPLPKARPRDLQSRLQHGYRDSVASSMLDTLQEEGSPIEPNRKSYVSFADSGSDSAAVSVTDPDGNIVRHSYFDEGSTIGSGSGSGSFGDVSKALNEDGEDADEDLQSFLSGESWDDSKWMKGALIGQGSFGCVYLALHAITGELLAVKQVEAPSPGANSQNDARKKSMIEALKREISLLRDLRHPNIVQYLGCGSSAEYLNIFLEYVPGGSVQTMLNSYGALPEPLVRSFVRQILNGLSYLHEREIIHRDIKGANILVDNKGTIKISDFGISKKIEATNLLNGANNNKHRPSLQGSVFWMAPEVVKQTSYTRKADIWSLGCLVVEMMTGTHPFPDCTQLQAIFKIGGGKATPTIPEDASTEAKAFLAQTFEMDHNKRPSADDLMLSPFLTPIT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias147-171Polar residues
Compositional bias187-249Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001234
EMBL· GenBank· DDBJ
EHA50924.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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