G4N7X0 · MST11_PYRO7
- ProteinMitogen-activated protein kinase kinae kinase MST11
- GeneMST11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids915 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Mitogen-activated protein kinase kinase kinase; part of the MST11-MST7-PMK1 MAP kinase (MAPK) cascade that is essential for appressorium formation, penetration and invasive growth (PubMed:15749760, PubMed:23454094).
The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes (PubMed:21283781).
MST11 acts as the upstream MAPKKK that directly phosphorylates MAPKK MST7 (Probable). MST11 but not MST7 may also be involved in the OSM1 MAPK pathway in response to osmotic stresses (PubMed:15749760).
The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes (PubMed:21283781).
MST11 acts as the upstream MAPKKK that directly phosphorylates MAPKK MST7 (Probable). MST11 but not MST7 may also be involved in the OSM1 MAPK pathway in response to osmotic stresses (PubMed:15749760).
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 647-655 | ATP (UniProtKB | ChEBI) | |||
Binding site | 670 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Biological Process | positive regulation of developmental process | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinae kinase MST11
- EC number
- Short namesMAPKKK MST11
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Magnaporthales > Pyriculariaceae > Pyricularia
Accessions
- Primary accessionG4N7X0
Proteomes
Organism-specific databases
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000453097 | 1-915 | Mitogen-activated protein kinase kinae kinase MST11 | ||
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-65 | Disordered | |||
Domain | 65-128 | SAM | |||
Region | 134-171 | Disordered | |||
Compositional bias | 147-171 | Polar residues | |||
Region | 183-249 | Disordered | |||
Compositional bias | 187-249 | Polar residues | |||
Domain | 263-353 | Ras-associating | |||
Domain | 641-911 | Protein kinase | |||
Domain
The N-terminal sterile alpha motif (SAM) domain, but not the Ras-associating (RA) domain, is essential for the function.
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length915
- Mass (Da)101,021
- Last updated2011-12-14 v1
- ChecksumD5D67F423E255DB2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 147-171 | Polar residues | |||
Compositional bias | 187-249 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM001234 EMBL· GenBank· DDBJ | EHA50924.1 EMBL· GenBank· DDBJ | Genomic DNA |