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G3YEJ3 · G3YEJ3_ASPNA

Function

function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Protein modification; protein glycosylation.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site228Proton donor
Active site377
Active site501Proton donor
Active site572
Binding site664Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasmic vesicle lumen
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Processcarbohydrate metabolic process
Biological Processmannose trimming involved in glycoprotein ERAD pathway
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    alpha-1,2-Mannosidase
  • EC number

Gene names

    • ORF names
      ASPNIDRAFT_56841

Organism names

Accessions

  • Primary accession
    G3YEJ3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane82-99Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond444↔487

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    699
  • Mass (Da)
    79,519
  • Last updated
    2011-12-14 v1
  • MD5 Checksum
    BCECA1E916A9C36012A298739E5C38E1
MSFQAPRNSSPFSSQQPFQNNYWRASRSPGTNGLPGYGFSPPTGISNSLNNPLAGDRTLPMYKDKPYFAPRRTGPRARRRKIIYSGLCLFVLLALWYYSGSGKPEWKTPDAEKGAELWKWVQSFEESEPPYDGSAATEKIDWEARREKVRDVFIVSWDGYAANAWGYDEYHPIAKNGRHMIEGGMGWIIVDALDTLMIMNLTSRVQHARSWIHNSLQYNQDHDVNTFETTIRMLGGLLSAHYLSTNYPELAPLTDDDTGAPGEDLYIEKATDLADRLLGAFESGTGIPYASINLNKSEGLPSYADNGASSTAEATTLQLEFKYLAKLTGEAEYWQAVEKVMEVVDDQKMEDGLLPIYVYPETGEFKGDNIRLGSRGDSYYEYLIKQYLQTQETEPIYKDMWDESLVGVRKHLITYTQNAKLTVLGERPAGLHGVLSPKMDHLVCFYPGTIALAATGGRPLSEARQSPDWGQRQEEEILLARELTKTCWATYLITKTGLAPEITYFNVDDPRVMETDMYPDSTIAKPSSGQQKASGELPLLSKSIYPVSDYSTKWRDDLNIHKQDRHNLQRPETVESLFYMYRITGDDIYRHWGWEMFKSFVKHTAVVEDIPKITGFTSLSNADDNPPVKRDNMESFWMAETLKYFYLLFSDRDFISLEDHVFNTEAHPLPRFKPTGELKTGWMRKSRTIPTSSEVEESV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACJE01000020
EMBL· GenBank· DDBJ
EHA19210.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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