G3XSI5 · AUND_ASPNA

Function

function

O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurasperone B, a dimeric gamma-naphthopyrone (PubMed:31067027).
The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).
YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable). A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B (PubMed:31067027).
AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A (PubMed:31067027).

Pathway

Secondary metabolite biosynthesis.

Features

Showing features for binding site, active site.

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TypeIDPosition(s)Description
Binding site275S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site326Proton acceptor

GO annotations

AspectTerm
Molecular FunctionO-methyltransferase activity
Biological Processmethylation
Biological Processsecondary metabolite biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    O-methyltransferase aunD
  • EC number
  • Alternative names
    • Aurasperone B biosynthesis cluster protein D

Gene names

    • Name
      aunD
    • ORF names
      ASPNIDRAFT_205346

Organism names

Accessions

  • Primary accession
    G3XSI5

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Leads to the accumulatio of aurasperone B and fonsecin B.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004498891-424O-methyltransferase aunD

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    46,776
  • Last updated
    2011-12-14 v1
  • Checksum
    B7E875CFD9D59175
MDDRLSSQLERYASQVTASATLIIRHLKSLKDEPSTLPSQTSVPTAVGTAQLRLAEAAFQLLHFTRDPGNVLTQLTVDLQVISAVRWLLHFEIFSLVPLEGSISYHELSSVANVPENLLRSHIRLAMTCHLFQESGPIGMVAHSPVSCQLASDPSLVSWGQYFANSVFPTATKNVNATAAWPGSKALNETAHNLAFNHHGSFFDYVSQDPARTVEFANSMKAVSTTSLFDTCHLCKSFDWSSLGDGVVVDMGGSTGHVSIALAESFPSLRFVVQDLPDVVSNSIRQLEERQLPLSVTTRIQFQGHSLLHMQPVKGAAVYLLRQILHDWPDREAVQILRSIVPALGPRSKIFIADIVLPEAGSIPATEEQVMRCNDLLLHQFTNTLERTLEDWQAIVSRVSDNLRIQHVYRDPGSILSLLVIETV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACJE01000004
EMBL· GenBank· DDBJ
EHA27206.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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