G3XSI5 · AUND_ASPNA
- ProteinO-methyltransferase aunD
- GeneaunD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids424 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurasperone B, a dimeric gamma-naphthopyrone (PubMed:31067027).
The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).
YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable). A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B (PubMed:31067027).
AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A (PubMed:31067027).
The first step in the biosynthesis of aurasperone B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).
YWA1 is then methylated by aunE at position C-6 to yield foncesin which is further methylated at position C-8 by aunD to produce fonsecin B (Probable). A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase aunB which catalyzes the oxidative dimerization of fonsecin B to aurasperone B (PubMed:31067027).
AunB also catalyzes the oxidative dimerization of rubrofusarin B into aurasperone A (PubMed:31067027).
Pathway
Secondary metabolite biosynthesis.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | O-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | secondary metabolite biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-methyltransferase aunD
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionG3XSI5
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Leads to the accumulatio of aurasperone B and fonsecin B.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000449889 | 1-424 | O-methyltransferase aunD | |||
Sequence: MDDRLSSQLERYASQVTASATLIIRHLKSLKDEPSTLPSQTSVPTAVGTAQLRLAEAAFQLLHFTRDPGNVLTQLTVDLQVISAVRWLLHFEIFSLVPLEGSISYHELSSVANVPENLLRSHIRLAMTCHLFQESGPIGMVAHSPVSCQLASDPSLVSWGQYFANSVFPTATKNVNATAAWPGSKALNETAHNLAFNHHGSFFDYVSQDPARTVEFANSMKAVSTTSLFDTCHLCKSFDWSSLGDGVVVDMGGSTGHVSIALAESFPSLRFVVQDLPDVVSNSIRQLEERQLPLSVTTRIQFQGHSLLHMQPVKGAAVYLLRQILHDWPDREAVQILRSIVPALGPRSKIFIADIVLPEAGSIPATEEQVMRCNDLLLHQFTNTLERTLEDWQAIVSRVSDNLRIQHVYRDPGSILSLLVIETV |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length424
- Mass (Da)46,776
- Last updated2011-12-14 v1
- ChecksumB7E875CFD9D59175