G3XAH6 · G3XAH6_HUMAN

  • Protein
    Poly(A) polymerase
  • Gene
    PAPOLA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions. Also active with manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

1724100200300400500600700
TypeIDPosition(s)Description
Binding site100-102ATP (UniProtKB | ChEBI)
Binding site109ATP (UniProtKB | ChEBI)
Binding site113Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site113Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site113-115ATP (UniProtKB | ChEBI)
Binding site115Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site115Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site167ATP (UniProtKB | ChEBI)
Binding site167Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site228ATP (UniProtKB | ChEBI)
Binding site237ATP (UniProtKB | ChEBI)
Binding site246-247ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpoly(A) RNA polymerase activity
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological ProcessRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Poly(A) polymerase
  • EC number

Gene names

    • Name
      PAPOLA

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    G3XAH6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 559 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)10PRIDEPhosphoserine
Modified residue (large scale data)23PRIDEPhosphothreonine
Modified residue (large scale data)24PRIDEPhosphoserine
Modified residue (large scale data)27PRIDEPhosphoserine
Modified residue (large scale data)109PRIDEPhosphothreonine
Modified residue (large scale data)537PRIDEPhosphoserine
Modified residue (large scale data)544PRIDEPhosphothreonine
Modified residue (large scale data)545PRIDEPhosphoserine
Modified residue (large scale data)617PRIDEPhosphoserine
Modified residue (large scale data)628PRIDEPhosphoserine
Modified residue (large scale data)629PRIDEPhosphoserine
Modified residue (large scale data)654PRIDEPhosphoserine
Modified residue (large scale data)660PRIDEPhosphoserine
Modified residue (large scale data)717PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Region1-22Disordered
Domain21-214Poly(A) polymerase nucleotidyltransferase
Domain219-363Poly(A) polymerase central
Domain366-434Poly(A) polymerase RNA-binding
Domain426-506Poly(A) polymerase RNA-binding
Region523-565Disordered
Compositional bias577-600Polar residues
Region577-690Disordered
Compositional bias611-641Polar residues
Compositional bias652-672Basic and acidic residues
Compositional bias673-690Polar residues

Sequence similarities

Belongs to the poly(A) polymerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    80,626
  • Last updated
    2011-11-16 v1
  • Checksum
    81465859D6E351F0
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEEQLDTETSTTQSETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P51003PAPOA_HUMANPAPOLA745
H0YJL4H0YJL4_HUMANPAPOLA181
H0YJ00H0YJ00_HUMANPAPOLA203
G3V457G3V457_HUMANPAPOLA111
G3V3I9G3V3I9_HUMANPAPOLA177
A0A0C4DGK1A0A0C4DGK1_HUMANPAPOLA238

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Compositional bias577-600Polar residues
Compositional bias611-641Polar residues
Compositional bias652-672Basic and acidic residues
Compositional bias673-690Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL163051
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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