G3XA57 · RFIP2_MOUSE
- ProteinRab11 family-interacting protein 2
- GeneRab11fip2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids512 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | nucleoplasm | |
Cellular Component | phagocytic cup | |
Cellular Component | recycling endosome membrane | |
Molecular Function | protein homodimerization activity | |
Molecular Function | protein kinase binding | |
Molecular Function | small GTPase binding | |
Biological Process | establishment of cell polarity | |
Biological Process | insulin secretion involved in cellular response to glucose stimulus | |
Biological Process | phagocytosis | |
Biological Process | positive regulation of protein localization to plasma membrane | |
Biological Process | regulated exocytosis | |
Biological Process | TRAM-dependent toll-like receptor 4 signaling pathway |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRab11 family-interacting protein 2
- Short namesRab11-FIP2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionG3XA57
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Recycling endosome membrane ; Peripheral membrane protein
Note: Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000424063 | 1-512 | Rab11 family-interacting protein 2 | |||
Sequence: MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLMQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSAHSMSDLTGSHLSSEKLKSSTVGPTHLLSRQIDSFGVVPESGSLKSPHRRTLSFDTSKLNQPGSIVDEGEHSFGRQSDPFTNVTASLPQKFATLPRKKNPFEESSEPWDSSMNLFSKPIEVRKESKREKREKVSLFERVTGKRDSRRPDKLNNGGSDSPCDLKSPSAFSENRQDYFEYESTNPFTAKFRASTIMPSSSFHVNPTSSEDLRKIPDNNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFTNS | ||||||
Modified residue | 227 | Phosphoserine; by MARK2 | ||||
Sequence: S | ||||||
Modified residue | 277 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3. Interacts with TICAM2; this interaction directs RAB11FIP2 to the phagosome.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-120 | C2 | ||||
Sequence: MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLMQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF | ||||||
Region | 15-102 | Necessary for its cellular translocation to the plasma membrane | ||||
Sequence: VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLMQGSPEKYILFLIVMHRSLVGLDKFLGQVA | ||||||
Region | 174-231 | Disordered | ||||
Sequence: RKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSAHSMSDL | ||||||
Compositional bias | 178-197 | Polar residues | ||||
Sequence: GVFSDTSSAIVPSTHMPDAN | ||||||
Region | 263-287 | Disordered | ||||
Sequence: PESGSLKSPHRRTLSFDTSKLNQPG | ||||||
Compositional bias | 270-287 | Polar residues | ||||
Sequence: SPHRRTLSFDTSKLNQPG | ||||||
Motif | 323-325 | NPF 1 | ||||
Sequence: NPF | ||||||
Compositional bias | 347-375 | Basic and acidic residues | ||||
Sequence: KESKREKREKVSLFERVTGKRDSRRPDKL | ||||||
Region | 347-390 | Disordered | ||||
Sequence: KESKREKREKVSLFERVTGKRDSRRPDKLNNGGSDSPCDLKSPS | ||||||
Motif | 406-408 | NPF 2 | ||||
Sequence: NPF | ||||||
Domain | 437-499 | FIP-RBD | ||||
Sequence: PDNNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVP | ||||||
Motif | 440-442 | NPF 2 | ||||
Sequence: NPF | ||||||
Region | 465-512 | Necessary for interaction with AP2A1, RAB11A, subcellular location, endocytosis activity and homooligomerization | ||||
Sequence: ELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFTNS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
G3XA57-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length512
- Mass (Da)58,207
- Last updated2011-11-16 v1
- Checksum5A6622C5E0B96728
G3XA57-2
- Name2
- Differences from canonical
- 507-512: GKFTNS → VYTQDHLSPGPPHLCGEATSTHS
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G3UW57 | G3UW57_MOUSE | Rab11fip2 | 370 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 178-197 | Polar residues | ||||
Sequence: GVFSDTSSAIVPSTHMPDAN | ||||||
Compositional bias | 270-287 | Polar residues | ||||
Sequence: SPHRRTLSFDTSKLNQPG | ||||||
Compositional bias | 347-375 | Basic and acidic residues | ||||
Sequence: KESKREKREKVSLFERVTGKRDSRRPDKL | ||||||
Alternative sequence | VSP_053310 | 507-512 | in isoform 2 | |||
Sequence: GKFTNS → VYTQDHLSPGPPHLCGEATSTHS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC105061 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC162855 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466585 EMBL· GenBank· DDBJ | EDL01829.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC089010 EMBL· GenBank· DDBJ | AAH89010.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139380 EMBL· GenBank· DDBJ | AAI39381.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139419 EMBL· GenBank· DDBJ | AAI39420.1 EMBL· GenBank· DDBJ | mRNA |