G3V323 · G3V323_HUMAN

  • Protein
    Glutathione peroxidase
  • Gene
    GPX2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

  • (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
    This reaction proceeds in the forward direction.
    EC:1.11.1.9 (UniProtKB | ENZYME | Rhea)
  • 2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol
    This reaction proceeds in the forward direction.
  • cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionperoxidase activity
Biological Processresponse to oxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione peroxidase

Gene names

    • Name
      GPX2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    G3V323

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 74 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Belongs to the glutathione peroxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    78
  • Mass (Da)
    8,737
  • Last updated
    2011-11-16 v1
  • Checksum
    0F15C9618203B23C
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLCGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQNCSG

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P18283GPX2_HUMANGPX2190
H0YJK8H0YJK8_HUMANGPX2134
G3V4J6G3V4J6_HUMANGPX278

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL139022
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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