Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.Masugi M., Yokoi M., Shigemoto R., Muguruma K., Watanabe Y., Sansig G., van der Putten H., Nakanishi S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCJ Neurosci 19:955-963 (1999)Mapped to36
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.Kaupmann K., Huggel K., Heid J., Flor P.J., Bischoff S., Mickel S.J., McMaster G., Angst C., Bittiger H.[...], Bettler B.View abstractCategorySequencesSourceMGI: 1351344PubMedEurope PMCNature 386:239-246 (1997)Cited in1Mapped to58
Physiological Features of the Neural Stem Cells Obtained from an Animal Model of Spinal Muscular Atrophy and Their Response to Antioxidant Curcumin.Adami R., Pezzotta M., Cadile F., Cuniolo B., Rovati G., Canepari M., Bottai D.View abstractSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 25:8364-8364 (2024)Mapped to18
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing.Hatanaka F., Suzuki K., Shojima K., Yu J., Takahashi Y., Sakamoto A., Prieto J., Shokhirev M., Nunez Delicado E.[...], Izpisua Belmonte J.C.View abstractSourceMGI: 1351344PubMedEurope PMCNat Commun 15:6191-6191 (2024)Mapped to18
Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy.Karafoulidou E., Kesidou E., Theotokis P., Konstantinou C., Nella M.K., Michailidou I., Touloumi O., Polyzoidou E., Salamotas I.[...], Grigoriadis N.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCCells 13:785-785 (2024)Mapped to18
Improved gene therapy for spinal muscular atrophy in mice using codon- optimized hSMN1 transgene and hSMN1 gene-derived promotor.Xie Q., Chen X., Ma H., Zhu Y., Ma Y., Jalinous L., Cox G.F., Weaver F., Yang J.[...], Xie J.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCEMBO Mol Med 16:945-965 (2024)Mapped to18
mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS.Kumar V., Lee K.Y., Acharya A., Babik M.S., Christian-Hinman C.A., Rhodes J.S., Tsai N.P.View abstractSourceMGI: 1351344PubMedEurope PMCEMBO Mol Med 16:506-522 (2024)Mapped to21
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy.Miller N., Xu Z., Quinlan K.A., Ji A., McGivern J.V., Feng Z., Shi H., Ko C.P., Tsai L.H.[...], Ma Y.C.View abstractSourceMGI: 1351344PubMedEurope PMCProc Natl Acad Sci U S A 120:e2300308120-e2300308120 (2023)Mapped to26
SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy.Valsecchi V., Errico F., Bassareo V., Marino C., Nuzzo T., Brancaccio P., Laudati G., Casamassa A., Grimaldi M.[...], Usiello A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCCommun Biol 6:1155-1155 (2023)Mapped to43
Diaphragm Fatigue in SMNDelta7 Mice and Its Molecular Determinants: An Underestimated Issue.Cadile F., Recchia D., Ansaldo M., Rossi P., Rastelli G., Boncompagni S., Brocca L., Pellegrino M.A., Canepari M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCInt J Mol Sci 24:14953-14953 (2023)Mapped to18
Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy.Lumpkin C.J., Harris A.W., Connell A.J., Kirk R.W., Whiting J.A., Saieva L., Pellizzoni L., Burghes A.H.M., Butchbach M.E.R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCSci Rep 13:10374-10374 (2023)Mapped to18
MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice.Chen T.H., Chang S.H., Wu Y.F., Yen Y.P., Hsu F.Y., Chen Y.C., Ming Y., Hsu H.C., Su Y.C.[...], Chen J.A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCMol Ther Nucleic Acids 32:144-160 (2023)Mapped to18
Base editing rescue of spinal muscular atrophy in cells and in mice.Arbab M., Matuszek Z., Kray K.M., Du A., Newby G.A., Blatnik A.J., Raguram A., Richter M.F., Zhao K.T.[...], Liu D.R.View abstractCategorySubcellular LocationSourceMGI: 1351344PubMedEurope PMCScience 380:eadg6518-eadg6518 (2023)Mapped to18
A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.Kim J.K., Jha N.N., Awano T., Caine C., Gollapalli K., Welby E., Kim S.S., Fuentes-Moliz A., Wang X.[...], Monani U.R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNeuron 111:1423-1439.e4 (2023)Mapped to41
Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model.Ojala K.S., Kaufhold C.J., Davey M.R., Yang D., Liang M., Wipf P., Badawi Y., Meriney S.D.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCHum Mol Genet 32:1901-1911 (2023)Mapped to18
Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons.Miralles M.P., Sansa A., Beltran M., Soler R.M., Garcera A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCFront Cell Neurosci 16:1054270-1054270 (2022)Mapped to18
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.Hennlein L., Ghanawi H., Gerstner F., Palominos Garcia E., Yildirim E., Saal-Bauernschubert L., Moradi M., Deng C., Klein T.[...], Jablonka S.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCJ Cell Biol 222:e202204113-e202204113 (2023)Mapped to36
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.Ikenaka A., Kitagawa Y., Yoshida M., Lin C.Y., Niwa A., Nakahata T., Saito M.K.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCLife Sci Alliance 6:e202201457-e202201457 (2023)Mapped to39
Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.Boido M., Gesmundo I., Caretto A., Pedrolli F., Schellino R., Leone S., Cai R., Sha W., Ghigo E.[...], Granata R.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCProc Natl Acad Sci U S A 120:e2216814120-e2216814120 (2023)Mapped to18
p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models.Buettner J.M., Sowoidnich L., Gerstner F., Blanco-Redondo B., Hallermann S., Simon C.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCFront Cell Neurosci 16:1038276-1038276 (2022)Mapped to26
Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation.Masugi-Tokita M., Kubota S., Kobayashi K., Yoshida T., Kageyama S., Sakamoto H., Kawauchi A.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCNeuroscience 509:10-19 (2023)Mapped to9
SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models.Franco-Espin J., Gatius A., Armengol J.A., Arumugam S., Moradi M., Sendtner M., Caldero J., Tabares L.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCBiomolecules 12:1524-1524 (2022)Mapped to22
SMN controls neuromuscular junction integrity through U7 snRNP.Tisdale S., Van Alstyne M., Simon C.M., Mentis G.Z., Pellizzoni L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1351344PubMedEurope PMCCell Rep 40:111393-111393 (2022)Mapped to18
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience.Woschitz V., Mei I., Hedlund E., Murray L.M.View abstractCategoryFunctionSourceMGI: 1351344PubMedEurope PMCSkelet Muscle 12:22-22 (2022)Mapped to18