Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., Kornhauser J.[...], Comb M.J.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCMol. Cell. Proteomics 13:372-387 (2014)Cited in99+99+Mapped to13
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (AUG-2024)Cited in99+
Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner.Wang H.C., Chen R., Yang W., Li Y., Muthukumar R., Patel R.M., Casey E.B., Denby E., Magee J.A.View abstractSourceMGI: 2444959PubMedEurope PMCCell Rep 43:114542-114542 (2024)Mapped to11
CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression.Cai H., Zhang B., Ahrenfeldt J., Joseph J.V., Riedel M., Gao Z., Thomsen S.K., Christensen D.S., Bak R.O.[...], Thomsen M.K.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCNat Commun 15:2088-2088 (2024)Mapped to13
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.Xie G., Lee J.E., Senft A.D., Park Y.K., Jang Y., Chakraborty S., Thompson J.J., McKernan K., Liu C.[...], Ge K.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCNat Genet 55:693-705 (2023)Mapped to40
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.Limberger T., Schlederer M., Trachtova K., Garces de Los Fayos Alonso I., Yang J., Hogler S., Sternberg C., Bystry V., Oppelt J.[...], Kenner L.View abstractCategoriesNames, Function, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCMol Cancer 21:89-89 (2022)Mapped to28
Identification of Jmjd3 as an Essential Epigenetic Regulator of <i>Hox</i> Gene Temporal Collinear Activation for Body Axial Patterning in Mice.Zhang F., Zhao X., Jiang R., Wang Y., Wang X., Gu Y., Xu L., Ye J., Chen C.D.[...], Zhao D.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCFront Cell Dev Biol 9:642931-642931 (2021)Mapped to99+
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.Chen R., Okeyo-Owuor T., Patel R.M., Casey E.B., Cluster A.S., Yang W., Magee J.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCCell Rep 34:108751-108751 (2021)Mapped to29
The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.Huisman C., Kim Y.A., Jeon S., Shin B., Choi J., Lim S.J., Youn S.M., Park Y., K C M.[...], Lee J.W.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCNat Commun 12:256-256 (2021)Mapped to99+
MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPbeta and C/EBPdelta.Lee J.E., Cho Y.W., Deng C.X., Ge K.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCMol Cell Biol 40:e00209-20 (2020)Mapped to23
MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.Ashokkumar D., Zhang Q., Much C., Bledau A.S., Naumann R., Alexopoulou D., Dahl A., Goveas N., Fu J.[...], Kranz A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCDevelopment 147:dev186999-dev186999 (2020)Mapped to99+
H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.Jang Y., Broun A., Wang C., Park Y.K., Zhuang L., Lee J.E., Froimchuk E., Liu C., Ge K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCNucleic Acids Res 47:607-620 (2019)Mapped to99+
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERalpha enhancer function.Gala K., Li Q., Sinha A., Razavi P., Dorso M., Sanchez-Vega F., Chung Y.R., Hendrickson R., Hsieh J.J.[...], Chandarlapaty S.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCOncogene 37:4692-4710 (2018)Mapped to95
MLL3/MLL4 are required for CBP/p300 binding on enhancers and super- enhancer formation in brown adipogenesis.Lai B., Lee J.E., Jang Y., Wang L., Peng W., Ge K.View abstractCategoriesFunction, InteractionSourceMGI: 2444959PubMedEurope PMCNucleic Acids Res 45:6388-6403 (2017)Mapped to62
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.Zhang Z., Christin J.R., Wang C., Ge K., Oktay M.H., Guo W.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCCell Rep 16:3146-3156 (2016)Mapped to36
Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.Arcipowski K.M., Bulic M., Gurbuxani S., Licht J.D.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCPLoS One 11:e0162515-e0162515 (2016)Mapped to11
Rebalancing gene haploinsufficiency in vivo by targeting chromatin.Fulcoli F.G., Franzese M., Liu X., Zhang Z., Angelini C., Baldini A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCNat Commun 7:11688-11688 (2016)Mapped to99+
A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.Starnes L.M., Su D., Pikkupeura L.M., Weinert B.T., Santos M.A., Mund A., Soria R., Cho Y.W., Pozdnyakova I.[...], Daniel J.A.View abstractSourceMGI: 2444959PubMedEurope PMCGenes Dev. 30:149-163 (2016)Cited in2Mapped to24
Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.Kim D.H., Rhee J.C., Yeo S., Shen R., Lee S.K., Lee J.W., Lee S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2444959PubMedEurope PMCHepatology 61:1012-1023 (2015)Mapped to18
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.Thompson C.L., Ng L., Menon V., Martinez S., Lee C.K., Glattfelder K., Sunkin S.M., Henry A., Lau C.[...], Jones A.R.View abstractCategoriesSequences, ExpressionSourceMGI: 2444959PubMedEurope PMCNeuron 83:309-323 (2014)Mapped to99+
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Chen C., Liu Y., Rappaport A.R., Kitzing T., Schultz N., Zhao Z., Shroff A.S., Dickins R.A., Vakoc C.R.[...], Lowe S.W.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCCancer Cell 25:652-665 (2014)Mapped to25
Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.Shao G.B., Chen J.C., Zhang L.P., Huang P., Lu H.Y., Jin J., Gong A.H., Sang J.R.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCIn Vitro Cell Dev Biol Anim 50:603-613 (2014)Mapped to71
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.Lee J.E., Wang C., Xu S., Cho Y.W., Wang L., Feng X., Baldridge A., Sartorelli V., Zhuang L.[...], Ge K.View abstractCategoryFunctionSourceMGI: 2444959PubMedEurope PMCElife 2:e01503-e01503 (2013)Mapped to99+