G3UWD2 · G3UWD2_MOUSE
- ProteinRunt-related transcription factor
- GeneRunx1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids451 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Biological Process | positive regulation of developmental process | |
Biological Process | positive regulation of multicellular organismal process | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameRunt-related transcription factor
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionG3UWD2
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MRIPVDASTSRRFTPPSTALSPGKM | ||||||
Domain | 50-178 | Runt | ||||
Sequence: SMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR | ||||||
Compositional bias | 170-186 | Basic and acidic residues | ||||
Sequence: VDGPREPRRHRQKLDDQ | ||||||
Region | 170-195 | Disordered | ||||
Sequence: VDGPREPRRHRQKLDDQTKPGSLSFS | ||||||
Region | 209-252 | Disordered | ||||
Sequence: MRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPW | ||||||
Compositional bias | 222-252 | Polar residues | ||||
Sequence: PRASLNHSTAFNPQPQSQMQDARQIQPSPPW | ||||||
Region | 268-290 | Disordered | ||||
Sequence: SVHPATPISPGRASGMTSLSAEL | ||||||
Region | 406-451 | Disordered | ||||
Sequence: NASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY | ||||||
Compositional bias | 408-439 | Polar residues | ||||
Sequence: STGAALLNPSLPSQSDVVETEGSHSNSPTNMP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length451
- Mass (Da)48,584
- Last updated2011-11-16 v1
- Checksum767BAD6FF4AD4D2E
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q03347 | RUNX1_MOUSE | Runx1 | 451 | ||
Q3UM65 | Q3UM65_MOUSE | Runx1 | 465 | ||
A0A087WPL0 | A0A087WPL0_MOUSE | Runx1 | 63 | ||
A0A087WR05 | A0A087WR05_MOUSE | Runx1 | 68 | ||
G3X9W7 | G3X9W7_MOUSE | Runx1 | 387 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 170-186 | Basic and acidic residues | ||||
Sequence: VDGPREPRRHRQKLDDQ | ||||||
Compositional bias | 222-252 | Polar residues | ||||
Sequence: PRASLNHSTAFNPQPQSQMQDARQIQPSPPW | ||||||
Compositional bias | 408-439 | Polar residues | ||||
Sequence: STGAALLNPSLPSQSDVVETEGSHSNSPTNMP |
Keywords
- Technical term