G3UNY7 · G3UNY7_MELGA

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

112381002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site408-413ATP (UniProtKB | ChEBI)
Binding site450-452ATP (UniProtKB | ChEBI)
Binding site496ATP (UniProtKB | ChEBI)
Binding site1024ATP (UniProtKB | ChEBI)
Binding site1099-1101ATP (UniProtKB | ChEBI)
Binding site1106-1110ATP (UniProtKB | ChEBI)
Binding site1146ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentaxon
Cellular Componentbasolateral plasma membrane
Cellular Componentdendrite
Cellular Componentexcitatory synapse
Cellular Componentglutamatergic synapse
Cellular Componenthippocampal mossy fiber to CA3 synapse
Cellular Componentneuronal cell body membrane
Cellular Componentpostsynaptic density
Cellular Componentpresynaptic active zone
Cellular Componentpresynaptic membrane
Cellular ComponentSchaffer collateral - CA1 synapse
Molecular FunctionATP binding
Molecular Functioncalcium- and calmodulin-responsive adenylate cyclase activity
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processcellular response to glucagon stimulus
Biological Processcellular response to morphine
Biological Processglucose mediated signaling pathway
Biological Processintracellular signal transduction
Biological Processlocomotory behavior
Biological Processlong-term memory
Biological Processneuroinflammatory response
Biological Processpositive regulation of CREB transcription factor activity
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of long-term synaptic depression
Biological Processpositive regulation of long-term synaptic potentiation
Biological Processpositive regulation of synaptic plasticity
Biological Processregulation of cellular response to stress
Biological Processregulation of cytosolic calcium ion concentration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate cyclase type 8
  • EC number

Gene names

    • Name
      ADCY8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris

Accessions

  • Primary accession
    G3UNY7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane172-190Helical
Transmembrane202-221Helical
Transmembrane254-271Helical
Transmembrane278-298Helical
Transmembrane310-330Helical
Transmembrane705-722Helical
Transmembrane728-750Helical
Transmembrane771-795Helical
Transmembrane824-842Helical
Transmembrane849-870Helical
Transmembrane890-906Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region45-107Disordered
Compositional bias46-64Polar residues
Compositional bias93-107Polar residues
Domain403-530Guanylate cyclase
Domain972-1112Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,238
  • Mass (Da)
    140,237
  • Last updated
    2021-09-29 v2
  • Checksum
    43466305D29C49B0
MELSEVRCLSDSDELYTINRTPPGSSRPQRLLWQTAVRHITEQRFIQEHSSSSGGSSSVGGKGFSSEETCCPNHHPHHHHHHHFRRQSAGRSLGSERHNNGGTKVFPERTSSNGDLGFLPLDCAPSNSDFFLNWGYTYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNILDVLTKLTLLFLHLTLASAPMDPIKGILLGFFTGIEVVICALVVVRKDTTSYTYLQYSGVVTWVAMATQILAAGLGCGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLVTSVLQLVMQLVMPRLAVTSLNQIAAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHKIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYKVEEGHGKERNEFLRKHNIETYLIKQPEESLLTLPEDIVKEAVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLVFITAIQSLLPSSRVIPMVIQFSILIMLHSALVLITTAEDYKCLPLMLRKTCCWINETYLARNVIIFASILINFLGAIINILWCDFDKPVPLKNQTFNSSASFSDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLAETIYASLFLQYDNLNHNGETDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSIALNESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSDRIQVPEETYLILKDRGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPLILQPRKLTGQYSLAAVVLGLVQSLNRQKQKQILNENNNSGIIKGHYNRRTLLTPGGSEAAAQAEGTRQN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G1NJG1G1NJG1_MELGAADCY81172

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias46-64Polar residues
Compositional bias93-107Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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