G3UNY7 · G3UNY7_MELGA
- ProteinAdenylate cyclase type 8
- GeneADCY8
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1238 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 408-413 | ATP (UniProtKB | ChEBI) | |||
Binding site | 450-452 | ATP (UniProtKB | ChEBI) | |||
Binding site | 496 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1024 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1099-1101 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1106-1110 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1146 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate cyclase type 8
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris
Accessions
- Primary accessionG3UNY7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 172-190 | Helical | |||
Transmembrane | 202-221 | Helical | |||
Transmembrane | 254-271 | Helical | |||
Transmembrane | 278-298 | Helical | |||
Transmembrane | 310-330 | Helical | |||
Transmembrane | 705-722 | Helical | |||
Transmembrane | 728-750 | Helical | |||
Transmembrane | 771-795 | Helical | |||
Transmembrane | 824-842 | Helical | |||
Transmembrane | 849-870 | Helical | |||
Transmembrane | 890-906 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 45-107 | Disordered | |||
Compositional bias | 46-64 | Polar residues | |||
Compositional bias | 93-107 | Polar residues | |||
Domain | 403-530 | Guanylate cyclase | |||
Domain | 972-1112 | Guanylate cyclase | |||
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,238
- Mass (Da)140,237
- Last updated2021-09-29 v2
- Checksum43466305D29C49B0
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G1NJG1 | G1NJG1_MELGA | ADCY8 | 1172 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 46-64 | Polar residues | |||
Compositional bias | 93-107 | Polar residues | |||
Keywords
- Technical term