G3RBF9 · G3RBF9_GORGO

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

1824100200300400500600700800
Type
IDPosition(s)Description
Binding site405Zn2+ (UniProtKB | ChEBI); catalytic
Active site406
Binding site409Zn2+ (UniProtKB | ChEBI); catalytic
Binding site415Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentapical plasma membrane
Cellular Componentcell surface
Cellular Componentcell-cell junction
Cellular Componentcytosol
Cellular Componentfocal adhesion
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentruffle membrane
Molecular Functionintegrin binding
Molecular Functioninterleukin-6 receptor binding
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Molecular Functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
Molecular FunctionNotch binding
Molecular FunctionPDZ domain binding
Molecular Functiontumor necrosis factor binding
Biological Processcell adhesion mediated by integrin
Biological Processcellular response to high density lipoprotein particle stimulus
Biological Processcommissural neuron axon guidance
Biological Processdefense response to Gram-positive bacterium
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Processpositive regulation of epidermal growth factor receptor signaling pathway
Biological Processpositive regulation of epidermal growth factor-activated receptor activity
Biological Processpositive regulation of G1/S transition of mitotic cell cycle
Biological Processpositive regulation of T cell chemotaxis
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of tumor necrosis factor-mediated signaling pathway
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processprotein processing
Biological Processresponse to hypoxia
Biological Processresponse to lipopolysaccharide
Biological Processsignal release
Biological Processwound healing, spreading of epidermal cells

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase domain 17

Gene names

    • Name
      ADAM17

Organism names

Accessions

  • Primary accession
    G3RBF9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane672-694Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_500345234218-824

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain223-474Peptidase M12B
Domain475-563Disintegrin
Region732-824Disordered
Compositional bias734-748Pro residues
Compositional bias757-780Basic and acidic residues
Compositional bias795-824Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    824
  • Mass (Da)
    93,007
  • Last updated
    2011-11-16 v1
  • Checksum
    A483048012846431
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHVRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I2YFC0A0A2I2YFC0_GORGOADAM17285

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias734-748Pro residues
Compositional bias757-780Basic and acidic residues
Compositional bias795-824Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABD030014354
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CABD030014355
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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