MicroRNA miR-145-5p regulates cell proliferation and cell migration in colon cancer by inhibiting chemokine (C-X-C motif) ligand 1 and integrin alpha2.
Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system.
Study showed that ITGA2 was markedly overexpressed in several malignant tumor cells and clinical tissues as pancreatic neoplasm. Further results suggest that ITGA2 plays a critical role in cancer cell progression and the regulation of PD-L1 by activating the STAT3 pathway.
The study unravels the interplay between integrin-alpha2beta1/-alpha5beta1 and EGFR in anoikis resistance and suggest that the resistant cells are cancer initiating or cancer stem cells which may serve as a promising target to combat metastasis of cancer.
bone marrow-derived mesenchymal stem cells -derived exosomes overexpressing miR-16-5p restricted the progression of colorectal cancer by downregulating ITGA2
DAR1 p110 could strongly enhance the adhesion of HCC tumor cells to ECM which was usually regarded as the initiation of tumor invasion. Such phenotype was caused due to up-regulation of ITGA2 both in mRNA and protein level.
we show that gene expression profiling of RUNX1 knock-down or mutated MK provides a suitable approach to identify novel RUNX1 targets among which downregulation of TREML1 and ITGA2 clearly contribute to the platelet phenotype of familial platelet disorder with predisposition to AML.
Carriage of a combination of mutant alleles in multiple genes including ITGB3+CYP2C19*2 or CYP2C19*2 + ITGA2 or CYP2C19*2 are possible predictors of CVE in patients after CABG
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.