Association of BglII Polymorphism in ITGA2 and (894G/T and -786T/C) Polymorphisms in eNOS Gene With Stroke Susceptibility in Tunisian Patients alpha2 Gene Polymorphism in alpha2beta1 Integrin and eNOS Gene Variants and Stroke.
Carriage of a combination of mutant alleles in multiple genes including ITGB3+CYP2C19*2 or CYP2C19*2 + ITGA2 or CYP2C19*2 are possible predictors of CVE in patients after CABG
Studied the association between integrin subunit alpha 2 (GPIa) and prostaglandin-endoperoxide synthase 2 (COX-2) genetic polymorphisms in Chinese ishemic stroke patients with or without aspirin resistance.
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin genes in the risk of recurrent IVF-ET failures. The coexistence of these SNPs was associated with increased IVF-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF-ET failure especially for younger women
Data indicate no association of maternal or fetal ITGA2 C807T SNP ITGB3 T1565C SNP PECAM1 CTG - GTG and SELP A/C polymorphisms with fetal growth restriction (FGR).
Meta-analysis found that glycoprotein Ia C807T T allele or the TT genotype the Ser-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.
The synonymous common variant GPIA rs1126643 increases the long-term adverse events risk of CABG by augmenting GPIa protein expression and enhancing platelet aggregation function.
The most common HPA genotypes among Saudis were HPA-1 a + b- (75%) HPA-2 a + b- (62%) HPA-3 a + b- (51.5%) HPA-4 a + b- (99%) HPA-5 a + b- (76.5%) HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a) except in the HPA-15 system where the (b) allele was found in 52% of the subjects.
Data indicate that in recurrent spontaneous abortion patients the expression levels of CD49b and LAG-3 (CD223) on CD14(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.
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