G3JF11 · CNS4_CORMM

Function

function

ABC-type transporter; part of the gene cluster that mediates the biosynthesis of cordycepin (COR) and pentostatin (PTN), two adenosine analogs with related bioactivity profiles as both mimic adenosine and can inhibit some of the processes that are adenosine dependent (PubMed:29056419, PubMed:37987892).
Mediates the pumping of pentostatin but not of cordycepin out of fungal cells (PubMed:29056419).
Decreasing intracellular pentostatin releases adenosine deaminase (ADA) inhibition, allowing ADA to deaminate cordycepin into non-toxic 3'-d (PubMed:29056419).

Miscellaneous

Cordycepin and pentostatin biosynthesis coupling is an important point of metabolic regulation where pentostatin safeguards cordycepin from deamination by inhibiting adenosine deaminase (ADA) activity. ADA is not inhibited until cordycepin reaches self-toxic levels, at which point ADA derepression occurs allowing for detoxification of cordycepin to 3'-deoxyinosine.

Biotechnology

Cordycepin has antitumor, antibacterial, antifungal, antivirus, and immune regulation properties; thus, cordycepin has important value in commerce, medicine, and scientific research.

Features

Showing features for binding site.

113641002003004005006007008009001,0001,1001,2001,300
TypeIDPosition(s)Description
Binding site779-786ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ABC-type transporter cns4
  • Alternative names
    • Cordycepin biosynthesis cluster protein 4

Gene names

    • Name
      cns4
    • ORF names
      CCM_04439

Organism names

Accessions

  • Primary accession
    G3JF11

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane435-455Helical
Transmembrane483-503Helical
Transmembrane508-528Helical
Transmembrane540-560Helical
Transmembrane567-587Helical
Transmembrane650-670Helical
Transmembrane1076-1094Helical
Transmembrane1105-1125Helical
Transmembrane1146-1166Helical
Transmembrane1185-1205Helical
Transmembrane1211-1231Helical
Transmembrane1245-1265Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Does not affect cordycepin production but significantly increases the cellular accumulation of pentostatin.

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004601831-1364ABC-type transporter cns4
Glycosylation152N-linked (GlcNAc...) asparagine
Glycosylation214N-linked (GlcNAc...) asparagine
Glycosylation610N-linked (GlcNAc...) asparagine
Glycosylation689N-linked (GlcNAc...) asparagine
Glycosylation711N-linked (GlcNAc...) asparagine
Glycosylation739N-linked (GlcNAc...) asparagine

Keywords

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain42-290ABC transporter 1
Region697-732Disordered
Compositional bias707-732Polar residues
Domain737-985ABC transporter 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,364
  • Mass (Da)
    151,877
  • Last updated
    2011-11-16 v1
  • Checksum
    4533C157F8D55720
MTEQQPDKEKRLGITWHDLTVKGIGKDAAFHENVASQFNIPSRVKESRAKPLLKTIVDNSHGCVKPGEMLLVLGRPGAGCTSLLKVLANRRLGYTKVTGEVWYGSMTADEAKQYRGQIVMNTEEELFFPTLTVQQTIDFATRMKVPHHLPTNLTNPEEFQKTNRDFLLRAMGIEHTGDTRVGNEFVRGVSGGERKRVSIIETMATRGSVFCWDNSTRGLDASTALEYVRCMRSMTDVLGLSSIVTLYQAGNGIYDLFDKVLVLDEGKQTFYGPMHQAKPFMEEMGFLYTDGANIADYLTSVTVPTERQVRPDMENRFPRNANELRSHYEKTQLKRTMALEYNYPNSPQAAEATKEFKEAVHLEKHPGLPAGSPLTVSFYTQVKSAIIRQYQLLWSDKATFLIPQCLNFVQALISGSLFYNAPHDSSGLAFKSGSLFFAVLLNALLSMSEVTGSFAARPVLAKHRGFALYHPAAYCFAQIAADIPLIAMQVTLFALPVYWMTGLKPTGEAFLTYWIITISVTMCMTALFRAIGAAFSSFDAAIKVTGFLMSALIMYTGFLIPKSRMHPWLGWIFWINPLAYGYEAVLSNEFHGQLIPCVNNNLVPNGPGYNNSEFQACAGIRGAPMGASVITGDQYLQGLSYSHAHVWRNFAIVWVWWALFVILTVYFTSNWSQVSGNSGYLVVPREKANKTMHTAVDEEVGSGPDSHDSRNRSGISPIGDKQETSTDGPSKIDSQLIRNTSVFTWKGLTYTVKTPSGDRVLLDHVQGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGIIKGSILVDGRDLPVSFQRSAGYCEQLDVHEPLATVREALEFSALLRQSRDTSVENKLKYVDTIIDLLEMHDIENTLIGTTAAGLSVEQRKRLTIGVELVSKPSILIFLDEPTSGLDGQAAFNIVRFLRKLADVGQAVLVTIHQPSASLFAQFDTLLLLAKGGKTVYFGNVGVNGATVNEYFGRNGAPCPQNTNPAEHMIDVVSGSKDWNEVWLASPEYTAMTQELDHLIRDAASKPPATLDDGHEFATPIWTQLKLVTHRNNTSLWRNTNYINNKLMLHITSGLLNGFSFWKIGNTVADLQMHLFTIFNFIFVAPGVIAQLQPLFLERRDIYEAREKKSKMYHWSAFATGLIVSELPYLVVCAVVYYMTWYYTVGFPSGSDKAGAVFFVVLMYEFIYTGIGQAIAAYTPNAIFAVLINPLIIAILVFFCGVYVPYAQIQAVWRYWLYYLDPFNYLMGSLLIFTTFDAPVHCEKEEFAVFNTPDGQTCGEYLAEYMQGLGSRTNLVNPSATRDCKVCQFRTGGDYLYTLNLKDYYYGWRDAGIVALFAISSYAKLRTKASKKAES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias707-732Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH126401
EMBL· GenBank· DDBJ
EGX93067.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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