G3JF11 · CNS4_CORMM
- ProteinABC-type transporter cns4
- Genecns4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1364 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of cordycepin (COR) and pentostatin (PTN), two adenosine analogs with related bioactivity profiles as both mimic adenosine and can inhibit some of the processes that are adenosine dependent (PubMed:29056419, PubMed:37987892).
Mediates the pumping of pentostatin but not of cordycepin out of fungal cells (PubMed:29056419).
Decreasing intracellular pentostatin releases adenosine deaminase (ADA) inhibition, allowing ADA to deaminate cordycepin into non-toxic 3'-d (PubMed:29056419).
Mediates the pumping of pentostatin but not of cordycepin out of fungal cells (PubMed:29056419).
Decreasing intracellular pentostatin releases adenosine deaminase (ADA) inhibition, allowing ADA to deaminate cordycepin into non-toxic 3'-d (PubMed:29056419).
Miscellaneous
Cordycepin and pentostatin biosynthesis coupling is an important point of metabolic regulation where pentostatin safeguards cordycepin from deamination by inhibiting adenosine deaminase (ADA) activity. ADA is not inhibited until cordycepin reaches self-toxic levels, at which point ADA derepression occurs allowing for detoxification of cordycepin to 3'-deoxyinosine.
Biotechnology
Cordycepin has antitumor, antibacterial, antifungal, antivirus, and immune regulation properties; thus, cordycepin has important value in commerce, medicine, and scientific research.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 779-786 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameABC-type transporter cns4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Cordycipitaceae > Cordyceps
Accessions
- Primary accessionG3JF11
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 435-455 | Helical | |||
Transmembrane | 483-503 | Helical | |||
Transmembrane | 508-528 | Helical | |||
Transmembrane | 540-560 | Helical | |||
Transmembrane | 567-587 | Helical | |||
Transmembrane | 650-670 | Helical | |||
Transmembrane | 1076-1094 | Helical | |||
Transmembrane | 1105-1125 | Helical | |||
Transmembrane | 1146-1166 | Helical | |||
Transmembrane | 1185-1205 | Helical | |||
Transmembrane | 1211-1231 | Helical | |||
Transmembrane | 1245-1265 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Does not affect cordycepin production but significantly increases the cellular accumulation of pentostatin.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000460183 | 1-1364 | ABC-type transporter cns4 | ||
Glycosylation | 152 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 214 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 610 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 689 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 711 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 739 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 42-290 | ABC transporter 1 | |||
Region | 697-732 | Disordered | |||
Compositional bias | 707-732 | Polar residues | |||
Domain | 737-985 | ABC transporter 2 | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,364
- Mass (Da)151,877
- Last updated2011-11-16 v1
- Checksum4533C157F8D55720
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 707-732 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JH126401 EMBL· GenBank· DDBJ | EGX93067.1 EMBL· GenBank· DDBJ | Genomic DNA |