The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland.
OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues a cellular process requiring reduction of vitamin K by a second enzyme VKORC1.
The three most frequently found sequence variants are associated with a substantial loss of rodenticide efficacy of first-generation anticoagulants as well as the second-generation compound bromadiolone and most probably also difenacoum.
Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.
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