G2XQ89 · G2XQ89_BOTF4

Function

function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular ComponentSet1C/COMPASS complex
Molecular Functionhistone H3K4 trimethyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
  • EC number

Gene names

    • ORF names
      BofuT4P87000006001

Organism names

Accessions

  • Primary accession
    G2XQ89

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the COMPASS (Set1C) complex.
Component of the Set1C/COMPASS complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-48Disordered
Compositional bias19-33Basic and acidic residues
Compositional bias34-48Polar residues
Compositional bias86-140Polar residues
Region86-149Disordered
Region194-221Disordered
Region385-428Disordered
Compositional bias390-422Pro residues
Region548-596Disordered
Compositional bias557-596Basic and acidic residues
Region651-683Disordered
Compositional bias728-765Basic and acidic residues
Region728-810Disordered
Compositional bias772-789Basic and acidic residues
Domain1123-1240SET
Domain1249-1265Post-SET

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,265
  • Mass (Da)
    141,277
  • Last updated
    2011-11-16 v1
  • Checksum
    6A1ECD15B97264C7
MSRASGASFAQFFPSAPRAAKDKAKEREKSKAQQADSPTTLSATDTQINAKALTDNASITRLSEDISIPLADPPTLTTEDNESVQGDILNGVGSASSHSSSGSSLFSVNNQLSNSMQASAGSRNINDSTPLTNADLSPNGVASPGNAKADMPFTATTRAALDNIKSEHVVAISNSATAEHTSTEPRVLARDPARGVKGKKCTYDPFHDPHIHSTKEKHNRRPHYKEFGLKDDAPPADPRLAKGSRLSYINTDYHNALSRLNHSPFMLPKYKYNPKTHYGPGPPTEIVVTGYDPLINFMKVTNVFTHYGQIAESSNKLHPETGSCLGFGTFRYRDTKKKDGTTLTAAEAAKKAVMRGSSVVGLGPRIKVQFDPQGKRSTRMLENALEKSKPEPLPLPPKEPPPPPKSEVAKSSGPPPSAPKGPAALSGRPQFRTGIVQAAIPTKPRQQTLIEDEPIAQQLEDEPYIFISKDYVPVIPATILHLKKRLKNHFLEDVRVDRTGYYVVFALSDEGRFEADRCYNSCNGTALFSYEMIMKLYLWGTGGRRHEHRDRASERGHHRRTRSPDPRLTEQKRRKEIEEIRKEEEADLEDEKRERAKNFDPAREAIEVIKRELMTHLMDKVKERIANPCLRNFMDPTNHIAKRRKLNIHDPNAKTPFIDDEEDQDNSNAVATPNSRIEDRGSLTAGKVNVTALPRIRKRAKAEKNRNVGFTDPFARPTRKAYVRPMHFLIGREDEDSDDDNEARSRTRGTEEIESRPRSRMGTDDEASDDDTDSMSRNVKERSQSLDTRDGESVSEANFSEPAIPTKKRKLDLHMEAAKKRQKKTDEELFGVPVAKIEPLSETSEAGISELDGFQKTESETEAALAAVAARKKAAKSAKRKKSKKQIFEEREALKRQQLGTTEDEIVPEEADEESEFEENIVDTAPVVTSVKWGISSYAPYPTVDDDFDNILDIDGLQNILKDDEDAGPALKIFKTDFELSDPATWAWRQGQIKSLNRNGYKGIVKDETTIPGYYVETSTGCARTEGTKKILNSEKSLYLPHRIKVQRAREEREAQAKRAGKDVVAEAAEAAKIAAEKLLARTSGRATRVNNRRYVADLNDQKKTLGGDTDVLRFNQLKKRKKPVKFARSAIHNWGLYAMENIAMNDMIIEYVGEKVRQQVADLRENRYLKSGIGSSYLFRIDENTVIDATKKGGIARFINHSCMPNCTAKIITVEKSKRIVIYALRDIAQNEELTYDYKFEREIGSTDRIPCLCGTPACKGFLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias19-33Basic and acidic residues
Compositional bias34-48Polar residues
Compositional bias86-140Polar residues
Compositional bias390-422Pro residues
Compositional bias557-596Basic and acidic residues
Compositional bias728-765Basic and acidic residues
Compositional bias772-789Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FQ790251
EMBL· GenBank· DDBJ
CCD42977.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp