G2XHB6 · G2XHB6_VERDV
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids838 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | interstrand cross-link repair | |
Biological Process | mitotic G1 DNA damage checkpoint signaling | |
Biological Process | mitotic sister chromatid cohesion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Plectosphaerellaceae > Verticillium
Accessions
- Primary accessionG2XHB6
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-411 | Helicase ATP-binding | |||
Compositional bias | 122-145 | Basic and acidic residues | |||
Region | 122-166 | Disordered | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length838
- Mass (Da)92,727
- Last updated2011-11-16 v1
- MD5 Checksum93AEC143A2CE5B4AEE48F8E23E8B92B5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 122-145 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS572720 EMBL· GenBank· DDBJ | EGY19214.1 EMBL· GenBank· DDBJ | Genomic DNA |