G2XHB6 · G2XHB6_VERDV

Function

function

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functioniron-sulfur cluster binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Biological Processestablishment of sister chromatid cohesion
Biological Processinterstrand cross-link repair
Biological Processmitotic G1 DNA damage checkpoint signaling
Biological Processmitotic sister chromatid cohesion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase CHL1
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase chl1
    • Chromosome loss protein 1
    • DNA 5'-3' helicase CHL1

Gene names

    • ORF names
      VDAG_09548

Organism names

Accessions

  • Primary accession
    G2XHB6

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain6-411Helicase ATP-binding
Compositional bias122-145Basic and acidic residues
Region122-166Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    92,727
  • Last updated
    2011-11-16 v1
  • MD5 Checksum
    93AEC143A2CE5B4AEE48F8E23E8B92B5
MGPPDEVIDFHHPYTPYDVQTQFMTEAYKVLQTGNGQIGILESPTGTGKSLSLICAALTWLRNHKSHENELSLGSAGVDLEDEPDWIIEQTLQRKRDDISKKWKQREQRLEQIRLKEKARAARSAKRRRIDDGNQKKVLKNPEDEEAEWLLDDADEPTSQSDALSGLGKETLEILSRYGLGGLKRDKEDEEILEDGVKLSQFVAELRRPSFPSSMPSSLVSGEHGAAVQAIQEPVKHLPLSSRQKLCINPAVSRLKTQSAINDRCAELQQPKSKNKCPYVPKEENLNKTHQFRDTAHATLPDIEDLFHLGKSLEVCPYYASRTAIAGTEIITLPYPLLLQKTAREALGIKLEGNIVIVDEAHNIMDAVANVYASEIRLGELKRARLMLGVYVKRFGKKLKGENRVMVGQPEQGIVDAKELLRSKGIDQINLFKLIQYIQTSKLAYKIESYVAYVEEDDSNKAAPRSSTPVLHTFVSFLVSLTNLSSEGRIFYQKLPGAAPDIQLSYLLLSPTHAFSSIATSARAVILAGGTMSPFDDYRAHLFPYLPEPKLTTLRCGHVIPPSNLCVRTLAASRAGDPNSTFEFSFQRRSDKAMVNQLGLAILNMCAVVPDGIVVFFPSYGYLDEVVAAWETTAAGESTPIWTRMQQRKAVFKESKGASSEEVLALYSEAILGDGTSDAPKPRGALLLSVVGGKMSEGINFSDRLGRAVMVVGLPYPNMHSPEWKAKTEYVEMTVLKRALEAEPGVDRAKAQAAAKQAARDFYENACMRAVNQSIGRAIRHRGDYAAIILCDRRYGTERIKGKLPGWIQGGIQGDGQESGLPQLMGALSGFFRGKRGT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias122-145Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS572720
EMBL· GenBank· DDBJ
EGY19214.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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