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G2WN15 · G2WN15_YEASK

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site45-48CoA (UniProtKB | ChEBI)
Binding site71CoA (UniProtKB | ChEBI)
Binding site124-126CoA (UniProtKB | ChEBI)
Binding site189substrate; ligand shared with subunit beta
Active site284Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      K7_LSC1
    • ORF names
      SYK7_065261

Organism names

Accessions

  • Primary accession
    G2WN15

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-128CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    35,023
  • Last updated
    2011-11-16 v1
  • MD5 Checksum
    BC89F10510C80EB3BE55C51A2678C1F3
MLRSTVSKASLKICRQFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DG000051
EMBL· GenBank· DDBJ
GAA26458.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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