G2WLW5 · G2WLW5_YEASK

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

134750100150200250300
TypeIDPosition(s)Description
Binding site16Zn2+ (UniProtKB | ChEBI); catalytic
Binding site18Zn2+ (UniProtKB | ChEBI); catalytic
Binding site204Zn2+ (UniProtKB | ChEBI); catalytic
Active site207Proton donor
Site228Important for catalytic activity
Binding site285Zn2+ (UniProtKB | ChEBI); catalytic
Binding site286substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function2'-deoxyadenosine deaminase activity
Molecular Functionadenine deaminase activity
Molecular Functionadenosine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      K7_AAH1
    • Synonyms
      AAH1
    • ORF names
      SYK7_059211

Organism names

Accessions

  • Primary accession
    G2WLW5

Proteomes

Subcellular Location

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-340Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    39,635
  • Last updated
    2011-11-16 v1
  • Checksum
    E25573A9F9EB7BB6
MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFPKSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVFYDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEATPFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDALDLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDRDVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGLLSRVDEVVTKYSH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DG000050
EMBL· GenBank· DDBJ
GAA25957.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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