G2HIZ0 · G2HIZ0_PANTR
- ProteinLeukotriene A(4) hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids611 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- leukotriene A4 + H2O = leukotriene B4
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Lipid metabolism; leukotriene B4 biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 135-137 | a peptide (UniProtKB | ChEBI) | |||
Binding site | 267-272 | a peptide (UniProtKB | ChEBI) | |||
Binding site | 296 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 297 | Proton acceptor | |||
Binding site | 300 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 319 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 384 | Proton donor | |||
Binding site | 564-566 | a peptide (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aminopeptidase activity | |
Molecular Function | leukotriene-A4 hydrolase activity | |
Molecular Function | metallopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | leukotriene biosynthetic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeukotriene A(4) hydrolase
- EC number
- Short namesLTA-4 hydrolase
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionG2HIZ0
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 464-608 | Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal | |||
Sequence similarities
Belongs to the peptidase M1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)69,313
- Last updated2011-11-16 v1
- ChecksumE0A9D79D8094B4D3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK306704 EMBL· GenBank· DDBJ | BAK63698.1 EMBL· GenBank· DDBJ | mRNA |