G2HIZ0 · G2HIZ0_PANTR

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Lipid metabolism; leukotriene B4 biosynthesis.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site135-137a peptide (UniProtKB | ChEBI)
Binding site267-272a peptide (UniProtKB | ChEBI)
Binding site296Zn2+ (UniProtKB | ChEBI); catalytic
Active site297Proton acceptor
Binding site300Zn2+ (UniProtKB | ChEBI); catalytic
Binding site319Zn2+ (UniProtKB | ChEBI); catalytic
Active site384Proton donor
Binding site564-566a peptide (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionaminopeptidase activity
Molecular Functionleukotriene-A4 hydrolase activity
Molecular Functionmetallopeptidase activity
Molecular Functionzinc ion binding
Biological Processleukotriene biosynthetic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Leukotriene A(4) hydrolase
  • EC number
  • Short names
    LTA-4 hydrolase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    G2HIZ0

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain464-608Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal

Sequence similarities

Belongs to the peptidase M1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    69,313
  • Last updated
    2011-11-16 v1
  • Checksum
    E0A9D79D8094B4D3
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCRDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK306704
EMBL· GenBank· DDBJ
BAK63698.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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