G2GWI3 · G2GWI3_9ENTR
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids242 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- orotidine 5'-phosphate + H+ = UMP + CO2
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 21 | substrate | |||
Binding site | 43 | substrate | |||
Active site | 70 | For OMPdecase activity | |||
Binding site | 70-79 | substrate | |||
Active site | 72 | For OMPdecase activity | |||
Active site | 72 | Proton donor | |||
Active site | 75 | For OMPdecase activity | |||
Binding site | 130 | substrate | |||
Binding site | 191 | substrate | |||
Binding site | 200 | substrate | |||
Binding site | 220 | substrate | |||
Binding site | 221 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > aphid secondary symbionts > Candidatus Regiella
Accessions
- Primary accessionG2GWI3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-236 | Orotidine 5'-phosphate decarboxylase | |||
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length242
- Mass (Da)25,971
- Last updated2011-11-16 v1
- MD5 ChecksumCD916079E34798443C22114578CCEEE2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGCA01000032 EMBL· GenBank· DDBJ | EGY29883.1 EMBL· GenBank· DDBJ | Genomic DNA |