G2GW87 · G2GW87_9ENTR

Function

function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site85-87substrate
Binding site87-88NADPH (UniProtKB | ChEBI)
Active site187Thioimide intermediate
Active site194Proton donor
Binding site226-227substrate
Binding site255-256NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionpreQ1 synthase activity
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent 7-cyano-7-deazaguanine reductase
  • EC number
  • Alternative names
    • 7-cyano-7-carbaguanine reductase
    • NADPH-dependent nitrile oxidoreductase
    • PreQ(0) reductase

Gene names

    • Name
      queF
    • ORF names
      Rin_00000140

Organism names

  • Taxonomic identifier
  • Strain
    • R5.15
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > aphid secondary symbionts > Candidatus Regiella

Accessions

  • Primary accession
    G2GW87

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-127NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    32,443
  • Last updated
    2011-11-16 v1
  • Checksum
    2CF682C574B68D10
MNNNQHVYSKHLGQKSQYIDTYNEKLLVAIPRSAGRKEIGLIDEQIPFHGFDLWTAYELSWLNKKGKPQVAMAEFTVPATSQNLIESKSLKLYLNSLNQSHLDSSEVHQHISKDLSHIAEAEVKVTLFEGMKNYSKKIDEPDYISIDESDIEVNDYKFNADHLKNAVTEKSPFVTEHLMSNLLKSNCLVTLQPDWASVFIKYEGKKIDREKLLRYIISFRKHNEFHEQCVERIFLDIKKYCHPQKLTVFARYTRRGGLDINPFRSDYESTSAIGRLVRQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCA01000005
EMBL· GenBank· DDBJ
EGY29991.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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