G2G9U4 · G2G9U4_9ACTN

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

117620406080100120140160
TypeIDPosition(s)Description
Active site133
Active site147

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      SZN_11323

Organism names

Accessions

  • Primary accession
    G2G9U4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane77-98Helical
Transmembrane105-123Helical
Transmembrane143-162Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    176
  • Mass (Da)
    18,137
  • Last updated
    2011-11-16 v1
  • MD5 Checksum
    556E0B80EB7C7DBE5B06B4ABBFE970CB
MTETHPAPTDVSPAAPRRGAGRRRIAALALAVAVAGGDLGAKAWAERALPGDPIPLGLLELRLAYNPGVAFSMGGNLPSWVVIAVTGVITAFVAIVGWRLAPKSWAAAGAAAFILGGAAANLIDRAGDGVVTDYLHTGWWPTFNMADVFIVTGGIAVAILAWRYPDEEPEKAESAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGBF01000025
EMBL· GenBank· DDBJ
EGX59766.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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