G1XJ45 · G1XJ45_ARTOA

Function

function

Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit that likely form a catalytic dimetal center.

Pathway

Lipid metabolism.
Sphingolipid metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site46Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site73Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid 2-hydroxylase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ceramide very long chain fatty acid hydroxylase
  • EC number

Gene names

    • ORF names
      AOL_s00097g372

Organism names

Accessions

  • Primary accession
    G1XJ45

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane197-215Helical
Transmembrane227-247Helical
Transmembrane306-325Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-90Cytochrome b5 heme-binding

Sequence similarities

Belongs to the sterol desaturase family. SCS7 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    43,292
  • Last updated
    2011-11-16 v1
  • MD5 Checksum
    0450E14DC3A072749F33DF3937CBBCBD
MITTMPSANLPTFTLAELAKNHSSKKSCYVTLGTKVYDLTDFLPDHPGGDDLILDYAGKDISDIIADPQSHVHSDAAYEILDDSLVGFLSPEDAKLANGSANGSTNGAAKTSAVPNGNPTYEATGMSTAEDLSVETDITNDFKTHKFIDLDKPMFMQVWRGRFSKEFYLKQVHRPRHYKGGDSAPLFGNFLEPLSKTAWYVIPIIWLPCVAYGLWMAGQGLTPEKLALCFASGIAIWTLVEYVLHRFLFHLDEYLPDNNVAITLHFLLHGIHHYLPMDRYRLVMPPTLFIALATPFWKLAHTLFAHNWYVGTGVFCGGIFGYICYDLTHYFLHHKKLPSYYQELKKYHLQHHFADYENGFGVTSRFWDRIFGTELPPLPQKTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADOT01000174
EMBL· GenBank· DDBJ
EGX46946.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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