G1U4Q6 · G1U4Q6_RABIT
- ProteinArylsulfatase
- GeneSULF2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids785 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 53 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 88 | Nucleophile | |||
Binding site | 88 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 317 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 318 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArylsulfatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionG1U4Q6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5023870508 | 25-785 | Arylsulfatase | ||
Modified residue | 88 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-374 | Sulfatase N-terminal | |||
Region | 489-510 | Disordered | |||
Domain | 519-580 | Extracellular sulfatase C-terminal | |||
Coiled coil | 544-571 | ||||
Region | 575-598 | Disordered | |||
Region | 765-785 | Disordered | |||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length785
- Mass (Da)90,952
- Last updated2019-12-11 v2
- ChecksumAAC45B3EC7FACCF1
Keywords
- Technical term