G1U4Q6 · G1U4Q6_RABIT

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

1785100200300400500600700
Type
IDPosition(s)Description
Binding site52Ca2+ (UniProtKB | ChEBI)
Binding site53Ca2+ (UniProtKB | ChEBI)
Active site88Nucleophile
Binding site88Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Binding site317Ca2+ (UniProtKB | ChEBI)
Binding site318Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular region
Cellular ComponentGolgi stack
Cellular Componentplasma membrane
Molecular Functionarylsulfatase activity
Molecular Functioncalcium ion binding
Molecular Functionglycosaminoglycan binding
Molecular FunctionN-acetylglucosamine-6-sulfatase activity
Biological Processbone development
Biological Processchondrocyte development
Biological Processembryonic skeletal system development
Biological Processesophagus smooth muscle contraction
Biological Processglial cell-derived neurotrophic factor receptor signaling pathway
Biological Processglomerular basement membrane development
Biological Processglomerular filtration
Biological Processheparan sulfate proteoglycan metabolic process
Biological Processinnervation
Biological Processliver regeneration
Biological Processnegative regulation of fibroblast growth factor receptor signaling pathway
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of vascular endothelial growth factor production
Biological Processregulation of hepatocyte proliferation
Biological Processresponse to wounding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Arylsulfatase
  • EC number
  • Alternative names
    • N-acetylglucosamine-6-sulfatase

Gene names

    • Name
      SULF2

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    G1U4Q6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_502387050825-785Arylsulfatase
Modified residue883-oxoalanine (Cys)

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, coiled coil.

Type
IDPosition(s)Description
Domain44-374Sulfatase N-terminal
Region489-510Disordered
Domain519-580Extracellular sulfatase C-terminal
Coiled coil544-571
Region575-598Disordered
Region765-785Disordered

Sequence similarities

Belongs to the sulfatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    785
  • Mass (Da)
    90,952
  • Last updated
    2019-12-11 v2
  • Checksum
    AAC45B3EC7FACCF1
MGPPSLLLCALWAALFSLLDGSSAFLAHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMGQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVSLLKNSRFYNYTLCRNGVKERHGFDYAKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRFFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMQFTNVLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYLVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPGNRFHLKKKMRVWRDSFLVERGKLLHKRDSDKVDAQEQNFLPRYQRVQDLCQRAEYQTACEQLGQYKASYVRSRSIRSVPVIVGGKVYHLGPASASQPRNLTKRHWPGAPEEQDDKDAGDFSGCYILENDTVQCDLDLYRSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCQKPSFHSQHSGRLKHKGSSLHPFRKGLPEDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPLWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGHKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG

Keywords

Genome annotation databases

Similar Proteins

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