G1TDP2 · G1TDP2_RABIT
- Protein3-hydroxy-3-methylglutaryl-coenzyme A reductase
- GeneHMGCR
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids826 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
Catalytic activity
- (R)-mevalonate + 2 NADP+ + CoA = (3S)-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+This reaction proceeds in the backward direction.
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | peroxisomal membrane | |
Molecular Function | coenzyme A binding | |
Molecular Function | GTPase regulator activity | |
Molecular Function | hydroxymethylglutaryl-CoA reductase (NADPH) activity | |
Molecular Function | NADPH binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | coenzyme A metabolic process | |
Biological Process | isoprenoid biosynthetic process | |
Biological Process | long-term synaptic potentiation | |
Biological Process | negative regulation of amyloid-beta clearance | |
Biological Process | negative regulation of protein catabolic process | |
Biological Process | negative regulation of protein secretion | |
Biological Process | regulation of ERK1 and ERK2 cascade | |
Biological Process | visual learning |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxy-3-methylglutaryl-coenzyme A reductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionG1TDP2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Peroxisome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-37 | Helical | |||
Transmembrane | 57-78 | Helical | |||
Transmembrane | 90-113 | Helical | |||
Transmembrane | 157-182 | Helical | |||
Transmembrane | 202-220 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Subunit
Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 61-218 | SSD | |||
Sequence similarities
Belongs to the HMG-CoA reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length826
- Mass (Da)90,656
- Last updated2019-12-11 v2
- MD5 ChecksumF97971EF6E53A5640C848DC7C1572E52
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F9DK35 | A0A5F9DK35_RABIT | HMGCR | 773 |
Keywords
- Technical term