G1TDP2 · G1TDP2_RABIT

Function

function

Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentperoxisomal membrane
Molecular Functioncoenzyme A binding
Molecular FunctionGTPase regulator activity
Molecular Functionhydroxymethylglutaryl-CoA reductase (NADPH) activity
Molecular FunctionNADPH binding
Biological Processcholesterol biosynthetic process
Biological Processcoenzyme A metabolic process
Biological Processisoprenoid biosynthetic process
Biological Processlong-term synaptic potentiation
Biological Processnegative regulation of amyloid-beta clearance
Biological Processnegative regulation of protein catabolic process
Biological Processnegative regulation of protein secretion
Biological Processregulation of ERK1 and ERK2 cascade
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • EC number

Gene names

    • Name
      HMGCR

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    G1TDP2

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Peroxisome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-37Helical
Transmembrane57-78Helical
Transmembrane90-113Helical
Transmembrane157-182Helical
Transmembrane202-220Helical

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain61-218SSD

Sequence similarities

Belongs to the HMG-CoA reductase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    826
  • Mass (Da)
    90,656
  • Last updated
    2019-12-11 v2
  • MD5 Checksum
    F97971EF6E53A5640C848DC7C1572E52
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDSCCRREPVVVRNNQKFCSVEEEAGINQERKVEVIKPLVAETDSPHRAAFVVGGSSFPDTSLVLETKEPEIELPKEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVLGACCENVIGYMPIPVGVVGPLCLDGKEFQVPMATTEGCLVASTNRGCRAICLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLHISMAGRNLYIRFQSRTGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKTVVCEAVIPAKVVREVSVAMNAGAVAGSWIGNGAAGTRSGTLGMPVLQAAALQMLGVQGACKDSPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLEGACTKKAA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F9DK35A0A5F9DK35_RABITHMGCR773

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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