G1TBQ3 · G1TBQ3_RABIT
- Proteinp-selectin
- GeneSELP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids768 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namep-selectin
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionG1TBQ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 709-733 | Helical | ||||
Sequence: ALTYVGGAVASTTGLVMAGTLLALL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 185↔194 | |||||
Sequence: CYPGFYGLEC | ||||||
Disulfide bond | 230↔257 | |||||
Sequence: CAEGFQLSGPSELECLASGVWTSELPQC | ||||||
Disulfide bond | 292↔319 | |||||
Sequence: CQPGYQVRGLDTLHCNGSGQWTAPLPTC | ||||||
Disulfide bond | 354↔381 | |||||
Sequence: CAEGFVLRGAEEVQCADSGQWTAPAPVC | ||||||
Disulfide bond | 416↔443 | |||||
Sequence: CDEGSLLVGASELECLDTGRWSAVPPEC | ||||||
Disulfide bond | 478↔505 | |||||
Sequence: CDKGFSLSGPERLDCTPSGTWTGSVPTC | ||||||
Disulfide bond | 540↔567 | |||||
Sequence: CNKGFKMEGSKNVECKASGRWSAPPPSC | ||||||
Disulfide bond | 610↔637 | |||||
Sequence: CKTGFTLMGDSALRCRPSGQWTAVTPTC | ||||||
Disulfide bond | 672↔699 | |||||
Sequence: CPKGQLLNGSARTECQENGQWSAPMPTC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG. Interacts (via C-type lectin domain) with alpha-IIb/beta3 integrin ITGA2B:ITGB3 and alpha-V/beta-3 integrin ITGAV:ITGB3. Interacts with alpha5/beta1 integrin ITGA5:ITGB1 and alpha4/beta1 integrin ITGA4:ITGB.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-159 | C-type lectin | ||||
Sequence: VAAWTYNYSIKAYSWNVSRAFCQKYYTDLVAIQNKNEIAHLNDVIPYYSSYYWIGIRKINDKWTWVGTKKPLTKEAENWADNEPNNKKNNEDCVEMYIKRSTSPGKWNDDRCRYKKRALCY | ||||||
Domain | 159-195 | EGF-like | ||||
Sequence: YTASCQDTSCSKQGECIETIGNYTCSCYPGFYGLECE | ||||||
Domain | 198-259 | Sushi | ||||
Sequence: RECGVPDVPEHTFMNCSHPLGMFSFHSQCSFHCAEGFQLSGPSELECLASGVWTSELPQCEV | ||||||
Domain | 260-321 | Sushi | ||||
Sequence: VQCEHLETPSKGTMDCVHPHADFAYGSSCKFECQPGYQVRGLDTLHCNGSGQWTAPLPTCEA | ||||||
Domain | 322-383 | Sushi | ||||
Sequence: VMCKPLESPDHGSMDCPPSEGAFPYNANCSFHCAEGFVLRGAEEVQCADSGQWTAPAPVCQA | ||||||
Domain | 384-445 | Sushi | ||||
Sequence: LQCQDLLPPNKAQVSCSHPFGAFRYQSVCRFSCDEGSLLVGASELECLDTGRWSAVPPECQA | ||||||
Domain | 446-507 | Sushi | ||||
Sequence: ITCTPLLSPQNGTMTCVQPHGDSSYKSTCQFICDKGFSLSGPERLDCTPSGTWTGSVPTCEA | ||||||
Domain | 508-569 | Sushi | ||||
Sequence: IKCPELFAPQQGSLDCSDIHGEFSVGSTCHFSCNKGFKMEGSKNVECKASGRWSAPPPSCKA | ||||||
Domain | 578-639 | Sushi | ||||
Sequence: VQCPTLTIPSQGTMSCRHHLAIFGLNTTCYFGCKTGFTLMGDSALRCRPSGQWTAVTPTCRA | ||||||
Domain | 640-701 | Sushi | ||||
Sequence: VKCSALHINNPVEMNCSVPWGNFSYGSTCTFYCPKGQLLNGSARTECQENGQWSAPMPTCQA |
Sequence similarities
Belongs to the selectin/LECAM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length768
- Mass (Da)84,187
- Last updated2013-11-13 v2
- Checksum0765A1C0CA6D4AC2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAGW02000035 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAGW02000036 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |