G1TBQ3 · G1TBQ3_RABIT

Function

function

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Cellular Componentplatelet alpha granule membrane
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent protein binding
Molecular Functionfucose binding
Molecular Functionheparin binding
Molecular Functionintegrin binding
Molecular Functionlipopolysaccharide binding
Molecular Functionoligosaccharide binding
Molecular Functionsialic acid binding
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processinflammatory response
Biological Processleukocyte tethering or rolling
Biological Processpositive regulation of leukocyte migration
Biological Processpositive regulation of leukocyte tethering or rolling
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of platelet activation
Biological Processregulation of integrin activation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    p-selectin
  • Alternative names
    • CD62 antigen-like family member P
    • Granule membrane protein 140
    • Leukocyte-endothelial cell adhesion molecule 3
    • Platelet activation dependent granule-external membrane protein

Gene names

    • Name
      SELP

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke inbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    G1TBQ3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane709-733Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond185↔194
Disulfide bond230↔257
Disulfide bond292↔319
Disulfide bond354↔381
Disulfide bond416↔443
Disulfide bond478↔505
Disulfide bond540↔567
Disulfide bond610↔637
Disulfide bond672↔699

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG. Interacts (via C-type lectin domain) with alpha-IIb/beta3 integrin ITGA2B:ITGB3 and alpha-V/beta-3 integrin ITGAV:ITGB3. Interacts with alpha5/beta1 integrin ITGA5:ITGB1 and alpha4/beta1 integrin ITGA4:ITGB.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-159C-type lectin
Domain159-195EGF-like
Domain198-259Sushi
Domain260-321Sushi
Domain322-383Sushi
Domain384-445Sushi
Domain446-507Sushi
Domain508-569Sushi
Domain578-639Sushi
Domain640-701Sushi

Sequence similarities

Belongs to the selectin/LECAM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    768
  • Mass (Da)
    84,187
  • Last updated
    2013-11-13 v2
  • Checksum
    0765A1C0CA6D4AC2
MASCLKVIWNQRFQKTVFGAAQLLYFGALISELTNQKEVAAWTYNYSIKAYSWNVSRAFCQKYYTDLVAIQNKNEIAHLNDVIPYYSSYYWIGIRKINDKWTWVGTKKPLTKEAENWADNEPNNKKNNEDCVEMYIKRSTSPGKWNDDRCRYKKRALCYTASCQDTSCSKQGECIETIGNYTCSCYPGFYGLECEYVRECGVPDVPEHTFMNCSHPLGMFSFHSQCSFHCAEGFQLSGPSELECLASGVWTSELPQCEVVQCEHLETPSKGTMDCVHPHADFAYGSSCKFECQPGYQVRGLDTLHCNGSGQWTAPLPTCEAVMCKPLESPDHGSMDCPPSEGAFPYNANCSFHCAEGFVLRGAEEVQCADSGQWTAPAPVCQALQCQDLLPPNKAQVSCSHPFGAFRYQSVCRFSCDEGSLLVGASELECLDTGRWSAVPPECQAITCTPLLSPQNGTMTCVQPHGDSSYKSTCQFICDKGFSLSGPERLDCTPSGTWTGSVPTCEAIKCPELFAPQQGSLDCSDIHGEFSVGSTCHFSCNKGFKMEGSKNVECKASGRWSAPPPSCKAIVSVLTPEVQCPTLTIPSQGTMSCRHHLAIFGLNTTCYFGCKTGFTLMGDSALRCRPSGQWTAVTPTCRAVKCSALHINNPVEMNCSVPWGNFSYGSTCTFYCPKGQLLNGSARTECQENGQWSAPMPTCQAGSLTVQEALTYVGGAVASTTGLVMAGTLLALLRKRFRQKDDGKNPLNPQSHLGTYGVFTNAAFDPIP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGW02000035
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAGW02000036
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp