G1SZ28 · G1SZ28_RABIT

Function

function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componenthistone deacetylase complex
Cellular Componentmale germ cell nucleus
Molecular Functionchromatin DNA binding
Molecular Functionhistone H3K9me/H3K9me2 demethylase activity
Molecular Functioniron ion binding
Molecular Functionnuclear androgen receptor binding
Molecular Functiontranscription coregulator activity
Biological Processandrogen receptor signaling pathway
Biological Processcellular response to leukemia inhibitory factor
Biological Processdemethylation
Biological Processformaldehyde biosynthetic process
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of stem cell differentiation
Biological Processregulation of stem cell population maintenance
Biological Processspermatid nucleus elongation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysine-specific demethylase
  • EC number

Gene names

    • Name
      KDM3A

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke inbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    G1SZ28

Proteomes

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region259-284Disordered
Compositional bias260-284Polar residues
Region307-336Disordered
Compositional bias310-328Polar residues
Compositional bias437-462Basic and acidic residues
Region437-476Disordered
Domain1061-1284JmjC

Domain

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

Sequence similarities

Belongs to the JHDM2 histone demethylase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,324
  • Mass (Da)
    147,571
  • Last updated
    2013-11-13 v2
  • MD5 Checksum
    F202D5664A6134821966D3B1FCD1168E
MVLTLGESWPVLVGKRFLSLSAAEGSEGGPDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGETWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAIVYRSLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQNVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVSCEEVPALKIVDPSLIHVEVVHDNFVACGNPTRMGAVKRKSSENNGSLISKQAKPCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEELSSCLNMKPEVLRTKADVLCKAALLSSQSSQMGTGDLKILSEPKGSCNQPNTSAGQESTLECVPQPLTDLPKDCLSTKPSSKEGLEIAHTPELQKHLEHAPSTSDVLSKKPEVKADVSSDSPNRCAEQKVEPSTLGCQSQNLKESSVKVDNESCYTKSNNKIQNAPSRKSVLTDPAKLRKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQAKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTRNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKKKNCQQGAAYKTFSWLRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDIKQTSPAGEKLAVGAALQQSPPVPEPAAAGGEAACKPVGGVKAACPASPSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTALHTFNSTILTPVSNNNSGFLRNLLNSSAGKTENGLKNTPKILDDIFASLVQNKTSTEVAKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNDKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLQQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLRASECSSSKP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F9D6E2A0A5F9D6E2_RABITKDM3A1273
A0A5F9C6M9A0A5F9C6M9_RABITKDM3A1235

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias260-284Polar residues
Compositional bias310-328Polar residues
Compositional bias437-462Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGW02007286
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAGW02007287
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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