G1SFY3 · G1SFY3_RABIT
- ProteinMitogen-activated protein kinase kinase kinase 7
- GeneMAP3K7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids606 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 63 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 7
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionG1SFY3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 36-291 | Protein kinase | |||
Region | 301-340 | Disordered | |||
Compositional bias | 303-340 | Polar residues | |||
Compositional bias | 354-382 | Polar residues | |||
Region | 354-391 | Disordered | |||
Compositional bias | 443-475 | Polar residues | |||
Region | 443-496 | Disordered | |||
Compositional bias | 482-496 | Polar residues | |||
Coiled coil | 533-564 | ||||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length606
- Mass (Da)67,168
- Last updated2011-10-19 v1
- Checksum9403325811AC5CCC
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F9D3N0 | A0A5F9D3N0_RABIT | MAP3K7 | 579 | ||
A0A5F9CJ95 | A0A5F9CJ95_RABIT | MAP3K7 | 584 | ||
A0A5F9CAU4 | A0A5F9CAU4_RABIT | MAP3K7 | 518 | ||
A0A5F9CWZ0 | A0A5F9CWZ0_RABIT | MAP3K7 | 577 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 303-340 | Polar residues | |||
Compositional bias | 354-382 | Polar residues | |||
Compositional bias | 443-475 | Polar residues | |||
Compositional bias | 482-496 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAGW02019433 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAGW02019434 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAGW02019435 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |