G1SFY3 · G1SFY3_RABIT

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site63ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentATAC complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionidentical protein binding
Molecular Functionlinear polyubiquitin binding
Molecular Functionmagnesium ion binding
Molecular FunctionMAP kinase activity
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionreceptor tyrosine kinase binding
Molecular Functionscaffold protein binding
Biological Processapoptotic process
Biological Processdefense response to bacterium
Biological ProcessI-kappaB phosphorylation
Biological Processimmune response
Biological Processinflammatory response
Biological Processinterleukin-1-mediated signaling pathway
Biological Processinterleukin-17A-mediated signaling pathway
Biological Processinterleukin-33-mediated signaling pathway
Biological ProcessJNK cascade
Biological Processp38MAPK cascade
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of JUN kinase activity
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of T cell cytokine production
Biological Processstress-activated MAPK cascade
Biological Processtoll-like receptor 4 signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase 7
  • EC number

Gene names

    • Name
      MAP3K7

Organism names

  • Taxonomic identifier
  • Strain
    • Thorbecke inbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    G1SFY3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

Type
IDPosition(s)Description
Domain36-291Protein kinase
Region301-340Disordered
Compositional bias303-340Polar residues
Compositional bias354-382Polar residues
Region354-391Disordered
Compositional bias443-475Polar residues
Region443-496Disordered
Compositional bias482-496Polar residues
Coiled coil533-564

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    67,168
  • Last updated
    2011-10-19 v1
  • Checksum
    9403325811AC5CCC
MSTASAASSSSSSSTSEMIEAPTQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNVEQVSATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATAAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F9D3N0A0A5F9D3N0_RABITMAP3K7579
A0A5F9CJ95A0A5F9CJ95_RABITMAP3K7584
A0A5F9CAU4A0A5F9CAU4_RABITMAP3K7518
A0A5F9CWZ0A0A5F9CWZ0_RABITMAP3K7577

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias303-340Polar residues
Compositional bias354-382Polar residues
Compositional bias443-475Polar residues
Compositional bias482-496Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGW02019433
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAGW02019434
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAGW02019435
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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