G1PQ88 · G1PQ88_MYOLU

Function

function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhistone deacetylase binding
Molecular Functionhistone deacetylase regulator activity
Molecular FunctionJUN kinase activity
Molecular Functionprotein phosphatase binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase binding
Biological Processcellular response to amino acid starvation
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to reactive oxygen species
Biological ProcessJUN phosphorylation
Biological Processnegative regulation of apoptotic process
Biological Processpeptidyl-serine phosphorylation
Biological Processpeptidyl-threonine phosphorylation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of cyclase activity
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of NLRP3 inflammasome complex assembly
Biological Processpositive regulation of protein metabolic process
Biological Processregulation of protein localization
Biological Processresponse to UV
Biological Processrhythmic process
Biological Processstress-activated MAPK cascade

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Stress-activated protein kinase JNK
  • EC number

Gene names

    • Name
      MAPK8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Myotis

Accessions

  • Primary accession
    G1PQ88

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain26-321Protein kinase
Region371-427Disordered
Compositional bias381-417Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    427
  • Mass (Da)
    48,295
  • Last updated
    2011-10-19 v1
  • Checksum
    B532A90B7E50D26F
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSPSVNDVSSMSTDPTLASDTDSSLEASAGPLGCCR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias381-417Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAPE02049992
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAPE02049993
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAPE02049994
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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