G1PDF3 · G1PDF3_MYOLU

Function

function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentalpha-beta T cell receptor complex
Cellular Componentcell body
Cellular Componentcell-cell junction
Cellular Componentdendritic spine
Cellular Componentendoplasmic reticulum
Cellular Componentexternal side of plasma membrane
Cellular ComponentGolgi apparatus
Cellular Componentimmunological synapse
Molecular Functionidentical protein binding
Molecular FunctionSH3 domain binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processapoptotic signaling pathway
Biological Processcalcium-mediated signaling
Biological ProcessCD4-positive, alpha-beta T cell proliferation
Biological Processcerebellum development
Biological Processdendrite development
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of smoothened signaling pathway
Biological Processnegative thymic T cell selection
Biological Processpositive regulation of calcium-mediated signaling
Biological Processpositive regulation of CD4-positive, alpha-beta T cell proliferation
Biological Processpositive regulation of cell-cell adhesion mediated by integrin
Biological Processpositive regulation of cell-matrix adhesion
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of interleukin-4 production
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of T cell anergy
Biological Processpositive regulation of type II interferon production
Biological Processpositive thymic T cell selection
Biological Processsmoothened signaling pathway
Biological ProcessT cell anergy
Biological ProcessT cell costimulation
Biological ProcessT cell receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-cell surface glycoprotein CD3 epsilon chain

Gene names

    • Name
      CD3E

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Myotis

Accessions

  • Primary accession
    G1PDF3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane119-144Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500341800522-199T-cell surface glycoprotein CD3 epsilon chain

Interaction

Subunit

The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain44-93Ig-like
Region153-186Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    22,377
  • Last updated
    2011-10-19 v1
  • MD5 Checksum
    9FF2C6AE681D1F9C81D0F2ED8AF08F3B
MPSRKLWHILGLCLLSVGAWGQEENKEIGRGEDCVGRFKVSISGTRVEVTCPEDPDSEQIKWERNGVQLTDQQEEHLLLDNFSEMEHSGHYTCYRGNSNNRNYLYLKARVCENCMEVDVMAVAGIIVADICVTLGLLLLVYYWSKNRKAKAKPMTRGVGAGGRPGGQNKERPPPVPNPDYEPIRKGQRELYAGLNQRGV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAPE02049441
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAPE02049442
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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