G1N9K2 · G1N9K2_MELGA

Function

function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell surface
Cellular Componentchloride channel complex
Cellular Componentcytosol
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentrecycling endosome membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionbicarbonate transmembrane transporter activity
Molecular Functionchloride channel inhibitor activity
Molecular Functionenzyme binding
Molecular Functionintracellularly ATP-gated chloride channel activity
Molecular Functionisomerase activity
Molecular FunctionPDZ domain binding
Molecular Functionprotein-folding chaperone binding
Molecular FunctionSec61 translocon complex binding
Biological Processcellular response to cAMP
Biological Processcellular response to forskolin
Biological Processcholesterol biosynthetic process
Biological Processcholesterol transport
Biological Processestablishment of localization in cell
Biological Processintracellular pH elevation
Biological Processmembrane hyperpolarization
Biological Processmulticellular organismal-level water homeostasis
Biological Processpositive regulation of enamel mineralization
Biological Processpositive regulation of exocytosis
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processresponse to endoplasmic reticulum stress
Biological Processsperm capacitation
Biological Processtransepithelial water transport
Biological Processvesicle docking involved in exocytosis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cystic fibrosis transmembrane conductance regulator
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 7
    • Channel conductance-controlling ATPase
    • cAMP-dependent chloride channel

Gene names

    • Name
      CFTR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris

Accessions

  • Primary accession
    G1N9K2

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane153-171Helical
Transmembrane229-250Helical
Transmembrane256-275Helical
Transmembrane338-361Helical
Transmembrane896-921Helical
Transmembrane954-973Helical
Transmembrane993-1012Helical
Transmembrane1024-1046Helical
Transmembrane1052-1071Helical
Transmembrane1143-1161Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain120-357ABC transmembrane type-1
Domain457-680ABC transporter
Domain897-1193ABC transmembrane type-1
Domain1246-1479ABC transporter
Region1488-1518Disordered
Compositional bias1501-1518Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,518
  • Mass (Da)
    172,026
  • Last updated
    2021-09-29 v3
  • Checksum
    7A859A9A53B2D047
MFGIYVCLLFETTGKTFMCALATSSLLVLFKENRLLYRSKQMVICLSSYSLWTKPILKKGYRQRLELSDIYQIPSADSADNLSEKLEREWDRELATSKKKPKLINALRRCFFWKFMFYGILLYLGEVTKSVQPLLLGRIIASYDPDNFSERSIAYYLGIGLCLLFLVRTLLIHPSIFGLHHIGMQIRIALFSLIYKKTLKLSSKVLDKISTGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLLWDMLQASAFAGLAFLIVMAFFQAWLGQMMMKYRDRRAGKINERLVITSEIIENIQSVKAYCWEDAMEKMIESLRETELKLTRKAAYVRYFNSSAFFFSGFFVVFLAVVPYAVTKGIILRKIFTTISFCIVLRMTVTRQFPGSVQTWYDSIGAINKIQDFLLKEEYKALEYNLTTTGVEVDKVTAFWDEGIGELFVKAKQENNNSKAPSNDNNLFFSNFPLHASPVLQDINFKIEKGELLAVSGSTGSGKTSLLMLIMGELEPSQGKIKHSGRISFSPQVSWIMPGTIKENIIFGVSYDEYRYKSVIQACQLEEDILKFPDKDYTVLGEGGIILSGGQRARISLARAVYKDADLYLMDSPFGYLDIFTEKEIFESCVCKLMANKTRILVTSKLEHLKIADKILILHEGSCYFYGTFSELQGQRPDFSSELMGFDSFDQFSAERRNSIITETLRRFSFEGESMGSRNEIKKQSFKQTSDFNDKRKNSIIINPLNAGRKLSIMQKNGTQVNGLEDGHVDPSERRISLVPDLEQGDVGLPRSNMLNSDHMLQSRRRQSVLSLMTGTSVNQGPHVSKKGSTTFRKMSMVPQTNLSSEIDIYTRRLSRDSILDITDEINEDDLKECFTDDAESMGTVTTWNTYFRYITIHKSLIFVLILCVIIFLLEVAASLVLLLFLQNRAAKINETQPENATSDSPPVIITDTSSYYMIYIYVGIADTLLAMGIFRGLPLVHTLITVSKTLHQKMVHAVLYAPMSAFNSLKAGGILNRFSKDTAILDDLLPLTVFDLIQLILIVIGAITVVSILQPYIFLASVPVIAAFIVLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVVFFSAVAFISIITTGDGPGRVGIILTLAMNIMGTLQWAVNSSIDVDSLMRSVSRIFKFIDMPTEEMKTIKPQKNNQFSDALVIENRHVKDEKNWPSGGQMTVTDLTARYTEGGTAVLENISFSISSGQTVGLLGRTGSGKSTLLFAFLRLLNTEGDIRIDGISWNTVSLQQWRKAFGVIPQKVFIFSGTFRKNLDPYGQWNDEEIWKVAEEVGLKSVIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPITSQVIRKTLKHAFADCTVILSEHRLEAILECQRFLVIEDNKMRQYESIQKLLSEKSSLRQAISHADRLKLLPAHRRNSSKRKPRPQICALQEETEEEVQETRL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A803XY86A0A803XY86_MELGACFTR1489
A0A803XV47A0A803XV47_MELGACFTR1475

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1501-1518Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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