G1MZN6 · G1MZN6_MELGA

Function

function

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.

Catalytic activity

Features

Showing features for binding site, active site.

150650100150200250300350400450500
TypeIDPosition(s)Description
Binding site95substrate
Active site137Proton acceptor
Binding site145substrate
Binding site172a divalent metal cation (UniProtKB | ChEBI)
Binding site174a divalent metal cation (UniProtKB | ChEBI)
Binding site260a divalent metal cation (UniProtKB | ChEBI)
Binding site299substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentheterochromatin
Cellular Componentneuronal cell body
Cellular ComponentNuRD complex
Cellular ComponentSin3-type complex
Cellular Componenttranscription repressor complex
Molecular FunctionE-box binding
Molecular Functionhistone deacetylase activity
Molecular Functionhistone deacetylase binding
Molecular Functionhistone decrotonylase activity
Molecular FunctionKrueppel-associated box domain binding
Molecular Functionmetal ion binding
Molecular FunctionNF-kappaB binding
Molecular Functionp53 binding
Molecular Functionpromoter-specific chromatin binding
Molecular FunctionRNA polymerase II core promoter sequence-specific DNA binding
Molecular Functiontranscription corepressor activity
Molecular Functiontranscription corepressor binding
Biological Processcircadian regulation of gene expression
Biological ProcessDNA methylation-dependent heterochromatin formation
Biological Processembryonic digit morphogenesis
Biological Processendoderm development
Biological Processepidermal cell differentiation
Biological Processeyelid development in camera-type eye
Biological Processfungiform papilla formation
Biological Processhippocampus development
Biological Processnegative regulation by host of viral transcription
Biological Processnegative regulation of androgen receptor signaling pathway
Biological Processnegative regulation of canonical NF-kappaB signal transduction
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of intrinsic apoptotic signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuron differentiation
Biological Processoligodendrocyte differentiation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of oligodendrocyte differentiation
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase 1
  • EC number
  • Short names
    HD1

Gene names

    • Name
      HDAC1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris

Accessions

  • Primary accession
    G1MZN6

Proteomes

Subcellular Location

Keywords

  • Cellular component

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain24-314Histone deacetylase
Region373-442Disordered
Compositional bias396-415Basic and acidic residues
Compositional bias422-438Basic and acidic residues

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    57,095
  • Last updated
    2021-09-29 v3
  • Checksum
    D1AF5FA09946E2FA
DGLLMGTQRDRCGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVISKVMETFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQPIPEDAVQEDSGDEEEEDPEKRISIRNSDKRISCDEEFSDSEDEGEGGRERRRKSKRGESRTQGVSPLSLGLAVNCLSLYFPVHFPMPLMGCCTASGVGVETWWFGCLVMGSEQGEVSVGGTAHLIKL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias396-415Basic and acidic residues
Compositional bias422-438Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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