G1MV24 · G1MV24_MELGA
- ProteinHistone-lysine N-methyltransferase
- GeneKMT2A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids3785 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 3655 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 3657 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 3699 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 3722-3723 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 3725 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 3773 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 3774 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 3775 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 3780 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris
Accessions
- Primary accessionG1MV24
Proteomes
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-20 | Basic and acidic residues | |||
Region | 1-153 | Disordered | |||
Compositional bias | 37-53 | Basic and acidic residues | |||
Compositional bias | 54-69 | Polar residues | |||
Compositional bias | 107-121 | Polar residues | |||
Compositional bias | 123-148 | Basic and acidic residues | |||
Compositional bias | 178-194 | Basic and acidic residues | |||
Region | 178-197 | Disordered | |||
Region | 236-382 | Disordered | |||
Compositional bias | 239-318 | Polar residues | |||
Compositional bias | 353-373 | Pro residues | |||
Compositional bias | 514-529 | Polar residues | |||
Region | 514-577 | Disordered | |||
Compositional bias | 545-577 | Polar residues | |||
Compositional bias | 600-644 | Polar residues | |||
Region | 600-802 | Disordered | |||
Compositional bias | 645-697 | Basic and acidic residues | |||
Region | 836-865 | Disordered | |||
Compositional bias | 844-859 | Polar residues | |||
Region | 902-964 | Disordered | |||
Domain | 945-993 | CXXC-type | |||
Region | 1003-1194 | Disordered | |||
Compositional bias | 1050-1073 | Basic and acidic residues | |||
Compositional bias | 1083-1098 | Polar residues | |||
Compositional bias | 1123-1137 | Polar residues | |||
Compositional bias | 1166-1189 | Polar residues | |||
Domain | 1226-1277 | PHD-type | |||
Domain | 1274-1328 | PHD-type | |||
Domain | 1361-1422 | PHD-type | |||
Region | 1458-1507 | Disordered | |||
Domain | 1498-1543 | Bromo | |||
Region | 1602-1664 | Disordered | |||
Compositional bias | 1617-1642 | Pro residues | |||
Domain | 1665-1773 | PHD-type | |||
Region | 1880-1928 | Disordered | |||
Compositional bias | 1900-1928 | Polar residues | |||
Compositional bias | 1940-1961 | Polar residues | |||
Region | 1940-2139 | Disordered | |||
Compositional bias | 1984-2096 | Polar residues | |||
Compositional bias | 2112-2139 | Polar residues | |||
Region | 2152-2259 | Disordered | |||
Compositional bias | 2167-2192 | Basic and acidic residues | |||
Compositional bias | 2216-2240 | Basic and acidic residues | |||
Compositional bias | 2241-2259 | Polar residues | |||
Compositional bias | 2281-2297 | Polar residues | |||
Region | 2281-2379 | Disordered | |||
Compositional bias | 2348-2379 | Polar residues | |||
Region | 2444-2470 | Disordered | |||
Region | 2536-2592 | Disordered | |||
Compositional bias | 2543-2560 | Basic and acidic residues | |||
Compositional bias | 2749-2763 | Polar residues | |||
Region | 2749-2790 | Disordered | |||
Region | 2821-2857 | Disordered | |||
Compositional bias | 2829-2857 | Polar residues | |||
Region | 2981-3060 | Disordered | |||
Compositional bias | 3009-3029 | Polar residues | |||
Compositional bias | 3314-3348 | Polar residues | |||
Region | 3314-3453 | Disordered | |||
Compositional bias | 3355-3375 | Basic and acidic residues | |||
Compositional bias | 3405-3453 | Polar residues | |||
Region | 3601-3624 | Disordered | |||
Domain | 3645-3761 | SET | |||
Domain | 3769-3785 | Post-SET | |||
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,785
- Mass (Da)413,387
- Last updated2021-09-29 v3
- ChecksumB895B1EAEB195B28
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-20 | Basic and acidic residues | |||
Compositional bias | 37-53 | Basic and acidic residues | |||
Compositional bias | 54-69 | Polar residues | |||
Compositional bias | 107-121 | Polar residues | |||
Compositional bias | 123-148 | Basic and acidic residues | |||
Compositional bias | 178-194 | Basic and acidic residues | |||
Compositional bias | 239-318 | Polar residues | |||
Compositional bias | 353-373 | Pro residues | |||
Compositional bias | 514-529 | Polar residues | |||
Compositional bias | 545-577 | Polar residues | |||
Compositional bias | 600-644 | Polar residues | |||
Compositional bias | 645-697 | Basic and acidic residues | |||
Compositional bias | 844-859 | Polar residues | |||
Compositional bias | 1050-1073 | Basic and acidic residues | |||
Compositional bias | 1083-1098 | Polar residues | |||
Compositional bias | 1123-1137 | Polar residues | |||
Compositional bias | 1166-1189 | Polar residues | |||
Compositional bias | 1617-1642 | Pro residues | |||
Compositional bias | 1900-1928 | Polar residues | |||
Compositional bias | 1940-1961 | Polar residues | |||
Compositional bias | 1984-2096 | Polar residues | |||
Compositional bias | 2112-2139 | Polar residues | |||
Compositional bias | 2167-2192 | Basic and acidic residues | |||
Compositional bias | 2216-2240 | Basic and acidic residues | |||
Compositional bias | 2241-2259 | Polar residues | |||
Compositional bias | 2281-2297 | Polar residues | |||
Compositional bias | 2348-2379 | Polar residues | |||
Compositional bias | 2543-2560 | Basic and acidic residues | |||
Compositional bias | 2749-2763 | Polar residues | |||
Compositional bias | 2829-2857 | Polar residues | |||
Compositional bias | 3009-3029 | Polar residues | |||
Compositional bias | 3314-3348 | Polar residues | |||
Compositional bias | 3355-3375 | Basic and acidic residues | |||
Compositional bias | 3405-3453 | Polar residues | |||
Keywords
- Technical term