G1MV24 · G1MV24_MELGA

Function

Catalytic activity

Features

Showing features for binding site.

137855001,0001,5002,0002,5003,0003,500
TypeIDPosition(s)Description
Binding site3655S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3657S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3699S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3722-3723S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3725Zn2+ (UniProtKB | ChEBI)
Binding site3773Zn2+ (UniProtKB | ChEBI)
Binding site3774S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3775Zn2+ (UniProtKB | ChEBI)
Binding site3780Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentMLL1 complex
Molecular Functionchromatin binding
Molecular Functionhistone H3K4 monomethyltransferase activity
Molecular Functionhistone H3K4 trimethyltransferase activity
Molecular Functionlysine-acetylated histone binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein-cysteine methyltransferase activity
Molecular Functionunmethylated CpG binding
Molecular Functionzinc ion binding
Biological Processanterior/posterior pattern specification
Biological Processcircadian regulation of gene expression
Biological Processdefinitive hemopoiesis
Biological Processembryonic hemopoiesis
Biological Processexploration behavior
Biological Processfibroblast proliferation
Biological Processhomeostasis of number of cells within a tissue
Biological Processmethylation
Biological Processnegative regulation of DNA methylation-dependent heterochromatin formation
Biological Processnegative regulation of fibroblast proliferation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpost-embryonic development
Biological Processprotein-containing complex assembly
Biological Processregulation of short-term neuronal synaptic plasticity
Biological Processspleen development
Biological ProcessT-helper 2 cell differentiation
Biological Processtranscription initiation-coupled chromatin remodeling
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase
  • EC number

Gene names

    • Name
      KMT2A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Meleagridinae > Meleagris

Accessions

  • Primary accession
    G1MV24

Proteomes

Subcellular Location

Keywords

  • Cellular component

Expression

Gene expression databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-20Basic and acidic residues
Region1-153Disordered
Compositional bias37-53Basic and acidic residues
Compositional bias54-69Polar residues
Compositional bias107-121Polar residues
Compositional bias123-148Basic and acidic residues
Compositional bias178-194Basic and acidic residues
Region178-197Disordered
Region236-382Disordered
Compositional bias239-318Polar residues
Compositional bias353-373Pro residues
Compositional bias514-529Polar residues
Region514-577Disordered
Compositional bias545-577Polar residues
Compositional bias600-644Polar residues
Region600-802Disordered
Compositional bias645-697Basic and acidic residues
Region836-865Disordered
Compositional bias844-859Polar residues
Region902-964Disordered
Domain945-993CXXC-type
Region1003-1194Disordered
Compositional bias1050-1073Basic and acidic residues
Compositional bias1083-1098Polar residues
Compositional bias1123-1137Polar residues
Compositional bias1166-1189Polar residues
Domain1226-1277PHD-type
Domain1274-1328PHD-type
Domain1361-1422PHD-type
Region1458-1507Disordered
Domain1498-1543Bromo
Region1602-1664Disordered
Compositional bias1617-1642Pro residues
Domain1665-1773PHD-type
Region1880-1928Disordered
Compositional bias1900-1928Polar residues
Compositional bias1940-1961Polar residues
Region1940-2139Disordered
Compositional bias1984-2096Polar residues
Compositional bias2112-2139Polar residues
Region2152-2259Disordered
Compositional bias2167-2192Basic and acidic residues
Compositional bias2216-2240Basic and acidic residues
Compositional bias2241-2259Polar residues
Compositional bias2281-2297Polar residues
Region2281-2379Disordered
Compositional bias2348-2379Polar residues
Region2444-2470Disordered
Region2536-2592Disordered
Compositional bias2543-2560Basic and acidic residues
Compositional bias2749-2763Polar residues
Region2749-2790Disordered
Region2821-2857Disordered
Compositional bias2829-2857Polar residues
Region2981-3060Disordered
Compositional bias3009-3029Polar residues
Compositional bias3314-3348Polar residues
Region3314-3453Disordered
Compositional bias3355-3375Basic and acidic residues
Compositional bias3405-3453Polar residues
Region3601-3624Disordered
Domain3645-3761SET
Domain3769-3785Post-SET

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,785
  • Mass (Da)
    413,387
  • Last updated
    2021-09-29 v3
  • Checksum
    B895B1EAEB195B28
MEKVKKKDLKSGEKRRGRPPTLTSVKFKLSQVKDTSDIQKGSKEDKESLKKIKRSPSTTFQQATKIKKLRTSKLSPLKSKFKPGAKLQIGRKSVQIVRRRGRPPSSERLKTSSSLVINSQLEKPQRIRKEKDGTPPPTKEEKTAVRQSPRRIKPVRIIPSTKRTDATIAKQLLQRAKKGAQKKIEKEAAKLQGRKGRTQLKNIRQFIMPVVSAISSRIIKTPKRFIEDEDYDPPIKISRLESTPNSRFSATSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEMQTLSEERSNTPEVHTPLPVSQSPENDNGDRRNRRFSITERSFGQRAAKKLSALPSVPQQQSSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIPLASPFLPTSAAPMQEKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSTPGATAPARLFSLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSSVGRTTTGTSATGVSSRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSTSDLTTLTPQSSVSSSLTSISVSSLATSALNSTFTFPSHSLTQSGESAERSQRQRKQTSTPAEPFSSSSPTPLFPWFTTSPQTERGRNKDRATEELSKDKDADKSVEKDKSREKDREREKENKRESRKEKRRKGSEIQSSSALFPVGKMPKEKVVSEDVAASSSAKKTAGRRKSTAIDPVADVSTAALVDTTAIKTKTSKKGRGGLDKSDLDLSPAVPSLEKEKALRLSTPASSTVKHSASSISSMLAQADKLPMTDKRVASLLKKAKAQLYKIEKSKSLKQADQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEEAEPLAPPIKPIKPVTRNKAQQEPPVKKGRRSRRCGQCSGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAAKKKEKKSKTNEKKESHSGKNQLDSGQKPTPPAVVPREDSAVKKSSEPARKPVEEKHEDGNSSAPPPEPKQTPASGTRKTGKQTAQPVQLPPSQPPSSGPLKKEAPKVTTSEPKKKQPPQPEIGTEQNKQKKIAPRPTFPVKQKPKEKEKPPPISKPENSTLNLLSTLTNGSSSKQKPPTDGVHRIRVDFKEDCEVENVWEMGGLGIVTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEESERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCINCTEQHPAEWRLALEKELQVSLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQEEQQPLDMEGVKRKMDQGGYISVLDFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVTSNSGMLPNAVLPPSLDHNYAQWQEREENNHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPISGSDRSREDSPELNPPPDVEDNRQCALCLKYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKSGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVLRRVFVDFEGISLRRKFLSGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIMECRPPVVEPDINSTVEHDDNRTIAHSPVPLTETLFKDSRNTPEIVNPPSPDRPMHSQTSSSCYYPTVSKGLRIRTPSYPSTQRSPGSRPLPSAGSPTPMTHEIVTVGDPLLSSGLKSIGSRRHSTSSLSQQQSKLRMISPTRAGNTYSRHSLSSVSSIGSSSEHEQSTKTADHFVGSVNSGTTSAPVQSCSSSSGSQKTAAASGTKTYQLDASQSTEGKHPSSSDLVAKSAPSKGEKVKTLTSRDPDYSAHSFSSGGNSKTSTQPNSSSGTEINVKIGTFQESAGSFSSKETVSFPSLHQRGPRKDRDQHLESVQPEKTTSVDEIDAKMLKSAGVNSRSPAASEQVVSATRDRRQKGKKIVKESFKEKHSLKSLTDSSQAGGGDEGNLTSEFGNQGLVTEQISQRLCNNIPAEKNVEKSPPSQGSSKSSVVLPEVAPKESQAPRKRTVKVTLTPLKMESEGQSKAAQQEGDAEPQPAGTELASSAEPSSNSESPEDNSVVQGSPNKAPTQESQNNAYENLPVQDNNLMLQDGTKAQEEGSYKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVVSSNTEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKVNQVTKRSGKENGTENLKLDRTEESGEKVQVTKSPAVHKTDPKMDNCHPVSRVKTQGQDSLEAQLSSLETGRRAHASTPSDKNLLDTFNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLTLGEGLGLDSNRGKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNHNRLAVISESSLSSSGERSMLALPSTESGEKRVTVTEKSTSSEGDAALLSPGVDPSPEGHMTPDHFIQGHIDAEHIASPPCGPVEQGHGSNQDLTRNSGTPGIQVPVSPTVPLQNQKYVPNSTDSPGASQISNAAVQTTPPHLKPAAEKLLVVNQNMQPLYVLQTLPNGVTQKIQLTPSVSSAQSVMETNASVLGPVGSGLTLTTGLNPSLPSSQSLYPPTSKGLLPMSHHQHIHPFSTATQTGFPPNIGSPSPGLLIGVQPPPDPQLLVSEANQRTDLGTTASTPAAALSKKRPISRLQSRKNKKLAPSGTPSAIAPPDMVSNMTLINFAPSQISNHPLDLGTIANSTSHRTVPNIIKRSKSGVMYFEQTSLLPQSGTASAVGTSPSVIGPDAGHLPTGPVSGLASSSSVLNVVSMQATAAPTTGGSVPSHVLGQSSVTLTSPGLLGDLGSISNLLIKASQQSLGLQEQHMTLPPASGMFSQLGTSQTPSTAAMTAASSICVLPSAQSMSMTVAQSSTDPEGSYQLQHMTQLLASKTGIASSQLDLGAASATAQLSSFSQLVDVPNSTRLEQNKVSSSVMHASSASPGGSPSSGQQSASSSVLGSSKMKPKIKRIQPSLEKGNGKKHKTSHMWTGSSEAHVPDRGTTAAPQVSAARTPAVKTDVQDAASTDQPSQTQCGQSTGQTAVLPESQSTKTSTNEQENAGSKAFEEEESTFSSPLMFWLQQEQKRKECLGEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGIIHDTVVFLIEQLYGAKHCHNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-20Basic and acidic residues
Compositional bias37-53Basic and acidic residues
Compositional bias54-69Polar residues
Compositional bias107-121Polar residues
Compositional bias123-148Basic and acidic residues
Compositional bias178-194Basic and acidic residues
Compositional bias239-318Polar residues
Compositional bias353-373Pro residues
Compositional bias514-529Polar residues
Compositional bias545-577Polar residues
Compositional bias600-644Polar residues
Compositional bias645-697Basic and acidic residues
Compositional bias844-859Polar residues
Compositional bias1050-1073Basic and acidic residues
Compositional bias1083-1098Polar residues
Compositional bias1123-1137Polar residues
Compositional bias1166-1189Polar residues
Compositional bias1617-1642Pro residues
Compositional bias1900-1928Polar residues
Compositional bias1940-1961Polar residues
Compositional bias1984-2096Polar residues
Compositional bias2112-2139Polar residues
Compositional bias2167-2192Basic and acidic residues
Compositional bias2216-2240Basic and acidic residues
Compositional bias2241-2259Polar residues
Compositional bias2281-2297Polar residues
Compositional bias2348-2379Polar residues
Compositional bias2543-2560Basic and acidic residues
Compositional bias2749-2763Polar residues
Compositional bias2829-2857Polar residues
Compositional bias3009-3029Polar residues
Compositional bias3314-3348Polar residues
Compositional bias3355-3375Basic and acidic residues
Compositional bias3405-3453Polar residues

Keywords

Genome annotation databases

Similar Proteins

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