G1LMV7 · G1LMV7_AILME

Function

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Can bind about 5 Ca2+ ions per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site, active site.

149350100150200250300350400450
Type
IDPosition(s)Description
Binding site116Zn2+ 2 (UniProtKB | ChEBI); catalytic; in inhibited form
Binding site148Ca2+ 1 (UniProtKB | ChEBI)
Binding site182Ca2+ 2 (UniProtKB | ChEBI)
Binding site192Zn2+ 1 (UniProtKB | ChEBI)
Binding site194Zn2+ 1 (UniProtKB | ChEBI)
Binding site199Ca2+ 3 (UniProtKB | ChEBI)
Binding site200Ca2+ 3 (UniProtKB | ChEBI)
Binding site207Zn2+ 1 (UniProtKB | ChEBI)
Binding site216Ca2+ 2 (UniProtKB | ChEBI)
Binding site218Ca2+ 2 (UniProtKB | ChEBI)
Binding site220Zn2+ 1 (UniProtKB | ChEBI)
Binding site222Ca2+ 3 (UniProtKB | ChEBI)
Binding site225Ca2+ 1 (UniProtKB | ChEBI)
Binding site225Ca2+ 3 (UniProtKB | ChEBI)
Binding site242Zn2+ 2 (UniProtKB | ChEBI); catalytic
Active site243
Binding site246Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site252Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site260Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site313Ca2+ 4 (UniProtKB | ChEBI)
Binding site359Ca2+ 5 (UniProtKB | ChEBI)
Binding site407Ca2+ 5 (UniProtKB | ChEBI)
Binding site454Ca2+ 4 (UniProtKB | ChEBI)
Binding site456Ca2+ 5 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Cellular Componentnucleus
Molecular Functioncalcium ion binding
Molecular Functioncollagen binding
Molecular Functioncore promoter sequence-specific DNA binding
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processbronchiole development
Biological Processcellular response to virus
Biological Processcollagen catabolic process
Biological Processelastin catabolic process
Biological Processextracellular matrix organization
Biological Processlung alveolus development
Biological Processnegative regulation of endothelial cell-matrix adhesion via fibronectin
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of type I interferon-mediated signaling pathway
Biological Processpositive regulation of epithelial cell proliferation involved in wound healing
Biological Processpositive regulation of interferon-alpha production
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of type I interferon-mediated signaling pathway
Biological Processprotein import into nucleus
Biological Processproteolysis
Biological Processregulation of defense response to virus by host
Biological Processwound healing, spreading of epidermal cells

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Matrix metallopeptidase 12

Gene names

    • Name
      MMP12

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ailuropoda

Accessions

  • Primary accession
    G1LMV7

Proteomes

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_503124203517-493
Disulfide bond306↔493
Modified residue388Phosphotyrosine; by PKDCC

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, repeat.

Type
IDPosition(s)Description
Domain129-288Peptidase metallopeptidase
Repeat303-352Hemopexin
Repeat353-399Hemopexin
Repeat401-449Hemopexin
Repeat450-493Hemopexin

Sequence similarities

Belongs to the peptidase M10A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    56,644
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    76219BD9F24A890C63330C9755B34C70
MKFLLLVLTLQVVASGTVPPTNSASSKENDVVFAQVTASGAVPWANSADPEDNVTYAQRYLENFYGFVMDRIPTTKMKVNRDFMEDKIREMQQFLGLKVTGKLDPPTLDVMHTPRCGVPDAHHFRTMQGRPVWKKRFITYRINNYTPDMRPADVDYAIQKAFQVWSDVTPLKFRKINSGEADIMIRFASGAHGDFTPFDGRGGVIAHAFGPGPGIGGDTHFDEAEIWTKNYKGTNLFLVAVHELGHSLGLSHSSDPKAIMFPTYSYVDPNTFRLSADDVRGIQSLYGRPERHQPSSNPDSRESATCDPNLSFDAVTTMGNKIFFFKDRFFWWRHPASPMSNVSLISSLWPTLPSGFQAAYEVGARNQVFLFKDDKYWLISNLRPQPRYPKNIHSLGFPDFVKKIDAAVFNPLLHKTYFFVDNQYWRYDERRQFMDSGYPKLITKYFPGIRPTIDAVYYYNRHYYFFQGSDIFEYDVVSQRVTKRLKQNIKLRC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G1LUN4G1LUN4_AILMEMMP12470

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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