G1LMV7 · G1LMV7_AILME
- ProteinMatrix metallopeptidase 12
- GeneMMP12
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids493 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Cofactor
Protein has several cofactor binding sites:
Note: Can bind about 5 Ca2+ ions per subunit.
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 116 | Zn2+ 2 (UniProtKB | ChEBI); catalytic; in inhibited form | |||
Binding site | 148 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 182 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 192 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 194 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 199 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 200 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 207 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 216 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 218 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 220 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 222 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 225 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 225 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 242 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Active site | 243 | ||||
Binding site | 246 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 252 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 260 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 313 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 359 | Ca2+ 5 (UniProtKB | ChEBI) | |||
Binding site | 407 | Ca2+ 5 (UniProtKB | ChEBI) | |||
Binding site | 454 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 456 | Ca2+ 5 (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ailuropoda
Accessions
- Primary accessionG1LMV7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-16 | ||||
Chain | PRO_5031242035 | 17-493 | |||
Disulfide bond | 306↔493 | ||||
Modified residue | 388 | Phosphotyrosine; by PKDCC | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 129-288 | Peptidase metallopeptidase | |||
Repeat | 303-352 | Hemopexin | |||
Repeat | 353-399 | Hemopexin | |||
Repeat | 401-449 | Hemopexin | |||
Repeat | 450-493 | Hemopexin | |||
Sequence similarities
Belongs to the peptidase M10A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length493
- Mass (Da)56,644
- Last updated2021-06-02 v2
- MD5 Checksum76219BD9F24A890C63330C9755B34C70
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G1LUN4 | G1LUN4_AILME | MMP12 | 470 |
Keywords
- Technical term