G0WK34 · G0WK34_AGRDO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Reduviidae > Harpactorinae > Harpactorini > Agriosphodrus

Accessions

  • Primary accession
    G0WK34

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-39Helical
Transmembrane51-73Helical
Transmembrane108-127Helical
Transmembrane147-169Helical
Transmembrane181-208Helical
Transmembrane228-253Helical
Transmembrane265-289Helical
Transmembrane301-324Helical
Transmembrane336-357Helical
Transmembrane377-398Helical
Transmembrane410-428Helical
Transmembrane448-471Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-510Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    511
  • Mass (Da)
    56,549
  • Last updated
    2011-10-19 v1
  • MD5 Checksum
    3249D66FF93DEBDA71CC901F9DF09A6D
MNKWIFSTNHKDIGTLYFLLGAWSGVVGTSLSLMIRIELGTPGTFIGNDQIYNVFVTAHAFIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLFPPSKTLLLISSIAEGGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGVSSILGAVNFISTIINMRPAGMTPERIPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIISMETGKNEAFGSLGMIYAMMTIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGSKQLNTPSLLWALGFIFLFTIGGLTGVVLANSSIDITLHDTYYVVAHFHYVLSMGAVFAIMGSFIQWYPLFSGLTMNPKWLKIQFFTMFVGVNLTFFPQHFLGLSGMPRRYSDYPDSYTCWNIISSLGSTISLISIMLFIFIIWESMVTKRQVLVAKQTSSNIEWMQKYPPAEHSYSELPLVCS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM071001
EMBL· GenBank· DDBJ
ADF65632.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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