G0USL2 · G0USL2_TRYCI

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site27substrate
Site27Important for catalytic activity
Binding site262substrate
Site262Important for catalytic activity
Binding site354substrate
Binding site381substrate
Binding site460substrate
Binding site468substrate
Binding site472substrate
Binding site519substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • ORF names
      TCIL3000_8_6020

Organism names

  • Taxonomic identifier
  • Strain
    • IL3000
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma > Nannomonas

Accessions

  • Primary accession
    G0USL2

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain351-525Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    669
  • Mass (Da)
    72,201
  • Last updated
    2011-10-19 v1
  • Checksum
    8F11C089057A8415
MISKDDLATNTIRCLAADGVQHAKSGHPGAPLGMAPVAYILWSEVMKFNCKDQHWADRDRFILSNGHASMLQYVMLHLSGYGVTMDDLKAFRQLNSCTPGHPERGVTPGVEVTTGPLGQGIGQGVGLAIAEAHLAATYNRPGYEIVDHWTYVFCGDGCLMEGVGQESLSLAGHLGLEKFVVVYDSNRISIDGSTDLAFTEDPVGKYEALGFHVILVKNGDSDFASIRAAFAECRAVKKRPKMIIVNTTIGFGSRSAGSEKVHGSPLGDDDIAQMKQQFGLCPTKKFHVEQSVYDIFKESSMAGARKQEEWSVLMGKYASEFPQEAAALQNQLDLKLPDGWKSRLPLNDKSIATRKASENVLAALLPSVPALFGGSADLSPSNLTRPGSAQLVDFQKATPEGRYLRYGVREHAMCAIMNGLHAHGGFVPFGGTFLNFFGYAMGAIRLSSLCHHQVVFVATHDSIGVGEDGPTHQPVELLALLRATPNLLVFRPSDQTETSASWALALENTKGPSILCLSRQNTVPQPNSSMQGVAKGAYVVLPANKPQLVIVSSGSEVSLAVDAAKALSPGIRVSVVSMPCQELFERQPADYYQCVFPSGVPVLSIEPYVAAGWERYSHYHIGMVGFGASAPAGQLYEHFNITVDHAVSIGRKLVSKYPDETAPARWVHL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE575321
EMBL· GenBank· DDBJ
CCC92375.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help