G0UJG8 · G0UJG8_TRYCI

Function

function

Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man7GlcNAc2-PP-dolichol to produce Man8GlcNAc2-PP-dolichol.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannosyltransferase
  • EC number

Gene names

    • ORF names
      TCIL3000_2_970

Organism names

  • Taxonomic identifier
  • Strain
    • IL3000
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma > Nannomonas

Accessions

  • Primary accession
    G0UJG8

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane62-82Helical
Transmembrane130-150Helical
Transmembrane162-183Helical
Transmembrane203-220Helical
Transmembrane232-251Helical
Transmembrane257-276Helical
Transmembrane312-339Helical
Transmembrane381-398Helical
Transmembrane405-424Helical
Transmembrane468-496Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500341049322-742Mannosyltransferase

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region433-461Disordered
Compositional bias436-461Basic and acidic residues

Sequence similarities

Belongs to the glycosyltransferase 22 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    742
  • Mass (Da)
    82,252
  • Last updated
    2011-10-19 v1
  • Checksum
    6E79D50EF7EFC8C9
MFLGSVLCFSALLLCIFVVELVCPYTKVEESFNMQAIHDFLLCRGVDCFDHLRSPGVVPRTFVGPWFIAVTVMIPFTFFSSYIVQLVSFFSYCAGYLLTDALQIVVSNGFGGVSSMEEFFALNPMLLSHASRIALGSLSCLSFWYVATGIDRLPGLKLSKGIGSLVIVPATGRCSIAATNFYLLVLLQFHLVFYASRPLPNTFGMILCSFACGCSCRGMYYKAIALLSAAAALFRCDTLVLLGPYALFVLVEGKVTFLRGIVVGMASVIAVVIFSVGMDSYLWGRLVWPEAVVLFFNTVENQSWKWGRQPAYWYFLVALPRAFLLLYPLLIVLICMSWWRVCSTIWSGGNRESAGNINSDLPHCSPLTRVFQVLMDVSEEYSILLVPSSLFVALYSALPHKEMRFIMIVFPWFLVPLAAAGARLCGEFLHESTQGRGGPNHKKESGWEKKGESNEKSRKGQFKGDAGFGMWSTGLVIVLVLLYTGHLATVGFSVYLSGDNYPGAVSLKRLQGTIEADLDNTTSCLNRRLARGGASNRSVSIFVDAFAAMSGINRFQKVHEVPLNSPRKSTAEKAESLLANSGRLTLLLAFPFRALFSVVNSVSAGNSLLQNEDLIHVDAAAGTSLGTIRNLRMAEKGFPTLSLTMQSRGLKMRYIKEETRFDEVTGLYNHEGVDYLIVRYSQRDLHRKHGKFDELFVTRMSNALPRLKYWVYRLLHLKGKNTGADSRDVEGEPFLIALGPRC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias436-461Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE575315
EMBL· GenBank· DDBJ
CCC89521.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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